Reflection-mode photoacoustic tomography using a flexibly-supported cantilever beam

• US 9,528,966 B2
• Filed: 10/21/2009
• Issued: 12/27/2016
• Est. Priority Date: 10/23/2008
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Wang, Lihong, Maslov, Konstantin
• Primary Examiner(s): TURCHEN, ROCHELLE DEANNA
• Application Number:
  US13/125,522
• Publication Number:
  US 20110201914A1
• Time in Patent Office: 2,624 Days
• Field of Search: 600/407, 600473-476
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/4866 Evaluating metabolism A61B5/083 takes precedence
• CPC Class Codes: A61B 8/00 Diagnosis using ultrasonic, sonic or infrasonic waves imaging of objects using sonar G01S15/00
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/4444 related to the probe
• CPC Class Codes: G01N 2291/02475 Tissue characterisation
• CPC Class Codes: G01N 2291/0427 Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever
• CPC Class Codes: G01N 29/0672 by acoustic tomography medical tomography A61B8/13
• CPC Class Codes: G01N 29/2418 using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046

Abstract

Noninvasively imaging biological tissue using a handheld device. A light pulse is focused into a predetermined area inside an object using a flexibly mounted cantilever beam, acoustic waves emitted by the object in response to the at least one light pulse are detected by a transducer, and an image of the predetermined area inside the object is generated based on a signal generated by the transducer representative of the acoustic waves.

Claims

1. A method for noninvasively imaging biological tissue using a handheld device, said method comprising:

focusing at least one light pulse suitable for photoacoustic imaging from an optical fiber into a predetermined area inside the tissue, wherein the optical fiber is positioned on a cantilever beam that is mounted at one extreme end using at least one flexure bearing;

detecting acoustic waves emitted from the predetermined area in response to the at least one light pulse using a transducer positioned on the cantilever beam; and

generating an image of the predetermined area based on a signal generated by the transducer representative of the acoustic waves;

wherein the optical fiber and the transducer positioned on the cantilever beam are configured to be sector scanned together.

2. A method in accordance with claim 1, wherein focusing at least one light pulse comprises focusing the at least one light pulse using at least one optical assembly.

3. A method in accordance with claim 1, further comprising inducing the acoustic waves in the predetermined area via optical absorption by the predetermined area of the at least one light pulse, wherein the predetermined area is heated using the at least one light pulse.

4. A method in accordance with claim 1, wherein detecting the acoustic waves comprises detecting the acoustic waves using a transducer array having a plurality of elements focused on the predetermined area.

5. A method in accordance with claim 1, further comprising digitizing the signal generated by the transducer, wherein the image is generated using the digitized signal.

6. A method in accordance with claim 1, further comprising sector scanning the cantilever beam by driving the cantilever beam and measuring a current location of the transducer using a motor controller, said focusing at least one light pulse comprises emitting the at least one light pulse at a predefined transducer location.

7. A method in accordance with claim 1, wherein the handheld device comprises:

a laser;

an optical assembly configured to focus at least one light pulse emitted by said laser into the predetermined area inside the object; and

the transducer, wherein said optical assembly and said transducer are positioned on the cantilever beam, the cantilever beam being flexibly mounted within a closed, liquid-filled container to facilitate one of one-dimensional scanning of the predetermined area inside the object and two-dimensional scanning of the predetermined area inside the object.

8. A method in accordance with claim 7, wherein said at least one flexure bearing is coupled to a linear stage.

9. A method in accordance with claim 7, wherein said cantilever beam comprises a fixed-end, flexible cantilever beam.

10. A method in accordance with claim 7, wherein said transducer comprises a single-element focused ultrasonic transducer.

11. A method in accordance with claim 7, wherein said transducer comprises an array of ultrasonic transducers.

12. A method in accordance with claim 7, wherein said container comprises an acoustically and optically transparent window positioned with respect to said optical assembly.

13. A method in accordance with claim 7, wherein said transducer transmits the signal to a digitizer for use in generating the image.

14. A method in accordance with claim 13, wherein said laser is configured to emit the at least one light pulse at a predefined transducer location based on a measurement of a current location of said transducer by a motor controller.

15. A method in accordance with claim 1, further comprising mounting the cantilever beam within a container.

16. A method in accordance with claim 15, further comprising filling the container with an immersion liquid such that the cantilever beam is suspended in the immersion liquid.

17. A method in accordance with claim 15, further comprising securing the container to the biological tissue using a coupling gel.

18. A method in accordance with claim 15, further comprising sealing the container with an optically and acoustically transparent membrane.

19. A method in accordance with claim 1, wherein the optical fiber and the transducer are coaxial with one another.

20. A method in accordance with claim 1, further comprising controlling an inclination angle of the cantilever beam using a sensor.