Implantable sensor

• US 9,532,738 B2
• Filed: 03/08/2012
• Issued: 01/03/2017
• Est. Priority Date: 09/09/2009
• Status: Active Grant

• Current Assignee: Indigo Diabetes NV
• Original Assignee: IMEC International, Universiteit Gent Vzw
• Inventors: Ryckeboer, Eva Maria Paula, Delbeke, Dana, Baets, Roel, Bogaerts, Wim
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): Liu, Chu Chuan (J J)
• Application Number:
  US13/415,392
• Publication Number:
  US 20120226118A1
• Time in Patent Office: 1,762 Days
• Field of Search: 600/310, 600/316, 600/317, 600/319, 600/321, 600/322, 600/326, 600/329, 600/332, 600/333, 600/340, 600/341, 600/342, 600/473, 600/476, 356/39
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: G02B 2006/12061 Silicon
• CPC Class Codes: G02B 2006/12123 Diode
• CPC Class Codes: G02B 2006/12138 Sensor
• CPC Class Codes: G02B 6/12021 Comprising cascaded AWG devices; AWG multipass configuration; Plural AWG devices integrated on a single chip

Abstract

A sensor is described for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor comprises a photonic integrated circuit, e.g. silicon-photonics, based radiation processor for spectrally processing radiation interacting with the sample. A continuous monitoring system also is described using such a sensor.

Claims

1. A sensor configured to sense glucose, urea, or lactate, the sensor being implantable in the body of a living creature or an object and configured for sensing in tissue or bodily fluids, the sensor comprising:

an integrated radiation source configured for coupling radiation generated by said source into a silicon photonics integrated circuit for irradiating said tissue or bodily fluids having at least one of glucose, urea, or lactate in said tissue or bodily fluid,

a silicon photonics integrated circuit configured to spectrally process the radiation interacting with the glucose or urea or lactate, wherein the silicon photonics integrated circuit comprises at least an integrated optical waveguide, an optical demultiplexer, and a detection element,

said integrated optical waveguide being configured for receiving radiation from said integrated radiation source and to send the radiation to the demultiplexer, said waveguide comprising a part configured for evanescent sensing within a measurement region from which the radiation interacting with the glucose, urea, or lactate is captured by said waveguide and senses the glucose, urea, or lactate by an evanescent tail of the radiation,

said optical demultiplexer being configured for spectrally processing the radiation to obtain spectrally resolved radiation

said integrated detection element being configured to detect different absorption or reflection bands of the glucose or urea or lactate from the spectrally resolved radiation to sense the glucose or urea or lactate, wherein the silicon photonics integrated circuit and the measurement region are configured for sampling free spectral measurements so that sensing can be performed without the need for extracting a sample or guiding a substrate of interest in a forced manner to the measurement region, and

wherein the radiation source and the silicon photonics integrated circuit form an integrated spectrometer, and

wherein said sensor is configured to be implantable in the body of a living creature or an object to sense glucose, urea, or lactate.

2. A sensor according to claim 1, wherein the measurement region is an open-space measurement region so that the measurement region is not enclosed by sensor walls.

3. A sensor according to claim 1, wherein the radiation source is a radiation source monolithically integrated with the radiation processor or heterogeneously integrated with the radiation processor or hybridly integrated with the radiation processor.

4. A sensor according to claim 3, wherein the radiation source is fibre-coupled to the radiation processor.

5. A sensor according to claim 1, wherein the photonics integrated circuit based sensor is adapted for operating in at least a wavelength region of 1560 nm to 1850 nm and/or is adapted for operating in at least a wavelength region of 2080 nm to 2325 nm.

6. A sensor according to claim 1, wherein the sensor is adapted for performing said spectrally processing radiation prior to interaction of the radiation with the glucose or urea or lactate to be sensed or wherein the sensor is adapted for performing said spectrally processing radiation after interaction of the radiation with the glucose or urea or lactate.

7. A sensor according to claim 1, wherein the sensor has a sensor configuration such that a measurement region of the sensor is surrounded by components of the sensor or such that a measurement region of the sensor lies substantially at one side of all components of the sensor.

8. A sensor according to claim 1, the sensor being configured for obtaining depth-related information regarding a sample or wherein the sensor is configured for spatially resolved detection and for deriving said depth-resolved information regarding the sample based thereon.

9. A sensor according to claim 1, wherein the silicon photonics integrated circuit is adapted for spatially resolved detection of scattered or reflected radiation and/or wherein the silicon photonics integrated circuit comprises a plurality of cascading wavelength multiplexers configured to increase a number of channels for spectrally processing radiation and/or wherein the silicon photonics integrated circuit comprises a plurality of tuneable filters configured to increase a number of channels for spectrally processing radiation.

10. A sensor according to claim 1, wherein frequency or time-domain multiplexing is used for increasing a number of channels for spectrally processing radiation and/or wherein a Vernier-shifted spectral response is used for increasing a number of channels for spectrally processing radiation.

11. A sensor according to claim 1, the sensor comprising an electronics component stacked with the sensing element and radiation source.

12. A sensor according to claim 1, said sensor being implantable in a bioreactor.

13. A continuous monitoring system comprising an implantable sensor according to claim 1, and

a readout system configured to wirelessly receive data sensed by the sensor.

14. The sensor according to claim 1, wherein the sensor being waveguide based comprises waveguide components having submicron dimensions.

15. A sensor according to claim 1, the sensor further comprising:

a coil antenna configured to provide power and transfer signals.

16. The sensor according to claim 15, wherein the sensor is circular having a diameter between 1 and 1.5 cm.

17. A sensor according to claim 1, wherein the sensor is configured for performing transmission measurements.

18. A sensor according to claim 1, wherein the sensor is adapted for operating in single mode condition.

19. A sensor according to claim 1, wherein said sensor is configured for subcutaneous, intramuscular, or ocular implantation.

20. A sensor configured to sense glucose, urea, or lactate, the sensor being implantable in the body of a living creature or an object and configured for sensing in tissue or bodily fluids, the sensor comprising:

an integrated radiation source configured for coupling radiation generated by said source into a silicon photonics integrated circuit for irradiating said tissue or bodily fluids having at least one of glucose, urea, or lactate in said tissue or bodily fluid,

a silicon photonics integrated circuit configured to spectrally process the radiation interacting with the glucose or urea or lactate, wherein the silicon photonics integrated circuit comprises at least an integrated optical waveguide, an optical multiplexer, and a detection element,

said optical multiplexer configured to combine radiation into a single path in said integrated optical waveguide,

said integrated optical waveguide being configured for receiving radiation from said integrated radiation source via said optical multiplexer and said integrated optical waveguide being configured for sending the radiation to the tissue or bodily fluid, said waveguide comprising a part configured for evanescent sensing within a measurement region from which the radiation interacting with the glucose, urea or lactate is captured by said waveguide and senses the glucose, urea or lactate by the evanescent tail of the radiation, and

said integrated detection element to detect different absorption bands of the glucose or urea or lactate from the spectrally processed radiation received from said integrated optical waveguide to sense the glucose or urea or lactate,

wherein the silicon photonics integrated circuit and the measurement region are being configured for sampling free spectral measurements so that sensing can be performed without the need for extracting sample or guiding the substance of interest in a forced manner to the measurement region, and

wherein the radiation source and the silicon photonics integrated circuit form an integrated spectrometer, and

wherein said sensor is configured to be implantable in the body of a living creature or an object.

21. A sensor according to claim 20, wherein said sensor is configured for subcutaneous, intramuscular, or ocular implantation.