Membrane for use with implantable devices
First Claim
1. An implantable device for continuous measurement of a glucose concentration, comprising:
- a sensing region configured to continuously measure a signal indicative of a glucose concentration in a host; and
a membrane located over the sensing region, wherein the membrane comprises a first layer and a second layer, wherein the first layer comprises an enzyme configured to catalyze a reaction with glucose as a reactant, wherein the second layer is formed of a blend comprising a polyurethane polymer and an acrylate polymer.
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Abstract
The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
513 Citations
7 Claims
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1. An implantable device for continuous measurement of a glucose concentration, comprising:
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a sensing region configured to continuously measure a signal indicative of a glucose concentration in a host; and a membrane located over the sensing region, wherein the membrane comprises a first layer and a second layer, wherein the first layer comprises an enzyme configured to catalyze a reaction with glucose as a reactant, wherein the second layer is formed of a blend comprising a polyurethane polymer and an acrylate polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification