Hydrogel compositions for tooth whitening

• US 9,532,935 B2
• Filed: 09/23/2014
• Issued: 01/03/2017
• Est. Priority Date: 05/01/2001
• Status: Expired due to Term

• Current Assignee: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences,, Corium LLC
• Original Assignee: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences,, Corium International, Inc.
• Inventors: Singh, Parminder, Cleary, Gary W., Mudumba, Sri, Feldstein, Mikhail M., Bayramov, Danir F.
• Primary Examiner(s): Maewall, Snigdha
• Application Number:
  US14/494,304
• Publication Number:
  US 20150139919A1
• Time in Patent Office: 833 Days
• Field of Search: 424/22, 424/731, 424/817, 424/86
• US Class Current: 1/1
• CPC Class Codes: A61C 19/066 Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
• CPC Class Codes: A61K 2800/262 Transparent; Translucent
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 2800/5422 nonionic
• CPC Class Codes: A61K 2800/5424 anionic
• CPC Class Codes: A61K 2800/59 Mixtures
• CPC Class Codes: A61K 6/20 Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• CPC Class Codes: A61K 6/30 Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• CPC Class Codes: A61K 6/65 Dyes
• CPC Class Codes: A61K 6/78 Pigments
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/817 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 11/02 : Preparations for deodorising, bleaching or disinfecting dentures
• CPC Class Codes: C08L 1/08 : Cellulose derivatives
• CPC Class Codes: C08L 2312/00 : Crosslinking
• CPC Class Codes: C08L 33/06 : of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
• CPC Class Codes: C08L 39/04 : Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
• CPC Class Codes: C08L 53/00 : Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides

Abstract

A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Claims

1. A tooth whitening system comprising:

an outer substrate that serves as an external surface of the system following application to a tooth surface;

a tooth contact adhesive layer adhered to the outer substrate, and

a removable release liner positioned on the tooth contact adhesive layer;

wherein the tooth contact adhesive layer comprises a solid composition comprising;

(a) a water-swellable, water-insoluble copolymer of methacrylic acid and ethyl acrylate;

(b) a blend of a poly(N-vinyl lactam) and a poly(alkylene glycol) oligomer capable of hydrogen bonding to the poly(N-vinyl lactam); and

(c) a whitening agent.

2. The tooth whitening system of claim 1, wherein the copolymer has a ratio of free carboxyl groups to ester groups in a range of about 1:

1 to 1;

2.

3. The tooth whitening system of claim 1, wherein the hydrophilic polymer is a poly(N-vinyl lactam) homopolymer.

4. The tooth whitening system of claim 1, wherein the poly(N-vinyl lactam) is selected from the group consisting of polyvinyl pyrrolidone, polyvinyl caprolactam, and blends thereof.

5. The tooth whitening system of claim 4, wherein the poly(N-vinyl lactam) is polyvinyl pyrrolidone.

6. The tooth whitening system of claim 4, wherein the poly(N-vinyl lactam) is polyvinyl caprolactam.

7. The tooth whitening system of claim 5, wherein the poly(N-vinyl lactam) has a number average molecular weight in the range of approximately 100,000 to 2,000,000.

8. The tooth whitening system of claim 7, wherein the poly(N-vinyl lactam) has a number average molecular weight in the range of approximately 500,000 to 1,500,000.

9. The tooth whitening system of claim 1, wherein the poly(alkylene glycol) oligomer has a molecular weight in the range of about 45 to 800.

10. The tooth whitening system of claim 9, wherein the poly(alkylene glycol) oligomer has a molecular weight in the range of about 45 to 600.

11. The tooth whitening system of claim 9, wherein the poly(alkylene glycol) oligomer is polyethylene glycol.

12. The tooth whitening system of claim 9, wherein the whitening agent is a peroxide.

13. The tooth whitening system of claim 12, wherein the peroxide is hydrogen peroxide or carbamide peroxide.

14. The tooth whitening system of claim 1, wherein the substrate is occlusive.

15. The tooth whitening system of claim 14, wherein the tooth contact adhesive layer is a pressure sensitive adhesive and is capable of absorbing water.

16. The tooth whitening system of claim 1, wherein the substrate is non-occlusive to enable hydration of the tooth contact adhesive layer in situ.

17. The tooth whitening system of claim 1, comprising from about 1-20 weight percent of the water-swellable, water insoluble copolymer;

from about 20-80 weight percent of the poly(N-vinyl lactam);

from about 10-50 weight percent of the poly(alkylene glycol) oligomer; and

from about 0.1 to 60 weight percent of the whitening agent.

18. The tooth whitening system of claim 1, comprising from about 6-12 weight percent of the water-swellable, water insoluble copolymer;

from about 40-60 weight percent of the poly(N-vinyl lactam);

from about 15-35 weight percent of the poly(alkylene glycol) oligomer; and

from about 0.1 to 30 weight percent of the whitening agent.

19. The tooth whitening system of claim 17, wherein the poly(N-vinyl lactam) is polyvinyl pyrrolidone, the poly(alkylene glycol) oligomer is polyethylene glycol, and the whitening agent is a peroxide.

20. The tooth whitening system of claim 18, wherein the poly(N-vinyl lactam) is polyvinyl pyrrolidone, the poly(alkylene glycol) oligomer is polyethylene glycol, and the whitening agent is a peroxide.

21. The tooth whitening system of claim 1, wherein release of the whitening agent is effected by absorption of water and desorption of the whitening agent via a swelling-controlled diffusion mechanism.

22. The tooth whitening system of claim 12, comprising from about 1 to 20 weight percent of the peroxide whitening agent.