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Placental tissue grafts and methods of preparing and using the same

  • US 9,533,011 B2
  • Filed: 02/03/2014
  • Issued: 01/03/2017
  • Est. Priority Date: 09/07/2007
  • Status: Active Grant
First Claim
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1. A method for preparing a de-epithelialized multilayer laminate comprising at least one amnion layer which method comprises:

  • placing at least one modified amnion layer comprising a first side which is an exposed basement membrane and a second side which retains a fibroblast cellular layer in contact with a second layer such that the amnion layer is positioned to contact its fibroblast cellular layer with the second layer;

    optionally adding one or more additional layers to said amnion or to said second layer; and

    dehydrating and laminating the layers under heated conditions;

    wherein the second layer is selected from the group consisting of amnion, chorion, allograft pericardium, allograft acellular dermis, amniotic membrane, Wharton'"'"'s jelly, a biocellulose polymer or copolymers, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, and a combination thereof.

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