×

EIF4E binding peptides

  • US 9,533,023 B2
  • Filed: 03/31/2015
  • Issued: 01/03/2017
  • Est. Priority Date: 04/27/2010
  • Status: Active Grant
First Claim
Patent Images

1. A method of inhibiting eukaryotic translation initiation factor 4E (eIF4E) by administering of a pharmaceutically effective amount of a modified eukaryotic translation initiation factor 4 gamma 1 (eIF4G1) peptide, wherein the peptide has been modified to stabilize the α

  • -helix, wherein the peptide comprises;

    (a) the amino acid sequence KKRYDREFLL*FQF (SEQ ID NO;

    10);

    or(b) the amino acid sequence KKRYDRE*LL*FQF (SEQ ID NO;

    2),wherein * represents a non-natural amino acid.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×