Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins
First Claim
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1. A HIRMAb-TNFR bifunctional decoy receptor fusion antibody comprising two fusion heavy chains of SEQ ID NO:
- 4, and two light chains of SEQ ID NO;
6.
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Abstract
Provided herein are compositions and related methods for delivering an IgG-decoy receptor to the CNS. The methods include systemic administration of a bifunctional decoy receptor-BBB receptor antibody fusion antibody comprising a receptor extracellular domain (ECD) covalently linked to an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor). In some embodiments, the compositions described herein are administered to treat a subject suffering from a CNS condition.
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Citations
1 Claim
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1. A HIRMAb-TNFR bifunctional decoy receptor fusion antibody comprising two fusion heavy chains of SEQ ID NO:
- 4, and two light chains of SEQ ID NO;
6.
- 4, and two light chains of SEQ ID NO;
Specification