Device for manipulating charged particles via field with pseudopotential having one or more local maxima along length of channel

• US 9,536,721 B2
• Filed: 05/04/2012
• Issued: 01/03/2017
• Est. Priority Date: 05/05/2011
• Status: Active Grant

• Current Assignee: Shimadzu Research Laboratory (Europe) Ltd. (Shimadzu Corporation)
• Original Assignee: Shimadzu Research Laboratory (Europe) Ltd. (Shimadzu Corporation)
• Inventors: Berdnikov, Alexander, Andreyeva, Alina, Giles, Roger
• Primary Examiner(s): MCCORMACK, JASON L
• Application Number:
  US14/115,134
• Publication Number:
  US 20140061457A1
• Time in Patent Office: 1,705 Days
• Field of Search: 250/281, 250/282, 250/283, 250/285, 250/288
• US Class Current: 1/1
• CPC Class Codes: H01J 49/0095 Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions ion/ion reactions H01J49/0072
• CPC Class Codes: H01J 49/06 Electron- or ion-optical arrangements
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421
• CPC Class Codes: H01J 49/065 having stacked electrodes, e.g. ring stack, plate stack

Abstract

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Claims

1. A device for manipulating charged particles, the device comprising:

a series of electrodes arranged so as to form a channel for transportation of the charged particles, the series of electrodes being adjacent to one another along a length of the channel;

a power supply unit adapted to provide supply voltages to said electrodes so as to create a non-uniform high-frequency electric field within said channel, the pseudopotential of said field having two or more local maxima along the length of said channel for transportation of charged particles, at least within a certain interval of time, wherein transportation of the charged particles along the length of the channel is provided by transposition of the at least two of said maxima of the pseudopotential such that the at least two of said maxima are caused to travel with time along the channel, at least within a certain interval of time and at least within a part of the length of the channel, wherein the supply voltages are high-frequency voltages synthesised using a digital method;

wherein the channel is filled with a buffer gas and the pressure of the buffer gas varies along the length of the channel, so that injection of charged particles into the device at an inlet of the device takes place at a higher pressure as compared with an outlet of the device;

wherein the device is configured to transport the charged particles to a low pressure region of the channel in which the pressure is less than 5×

10−

3 mbar;

wherein in the process of transportation of the charged particles, equalisation of kinetic energies of charged particles occurs due to collisions and energy exchange between charged particles and buffer gas molecules.

2. A device according to claim 1 wherein additional voltages are applied to the electrodes;

said voltages being DC voltages and/or quasi-static voltages and/or AC voltages and/or pulsed voltages and/or high-frequency voltages, so as to control the time synchronisation of the transportation of the charged particles.

3. A device according to claim 1, wherein the device comprises more than one stage of differential pumping such that the pressure of the buffer gas varies along the length of the device.

4. A device according to claim 1, wherein the claimed device is used in an interface for transportation of charged particles from gas-filled ion sources into a mass analyser.

5. A device according to claim 4 wherein the gas filled ion source is selected from:

Electrospray Ionisation (ESI) ion source, Atmospheric Pressure Ionization (API) ion source, Atmospheric Pressure Chemical Ionization (APCI) ion source, Atmospheric Pressure Photo Ionisation (APPI) ion source, Inductively Coupled Plasma (ICP) ion source, Electron Impact (EI) ion source, Chemical Ionisation (CI) ion source, Photo Ionisation (PI) ion source, Thermal Ionisation (TI) ion source, gas discharge ionisation ion source, fast atom bombardment (FAB) ion source, ion bombardment ionisation in Secondary Ion Mass Spectrometry (SIMS) ion source, and ion bombardment ionisation in Liquid Secondary Ion Mass Spectrometry (LSIMS) ion source.

6. A device according to claim 1, wherein the device is associated with a charged particle detector and wherein operation of the device is time-synchronised with the charged particle detector.

7. A device according to claim 1, wherein the device is adapted to provide extraction of charged particles from the channel in a direction orthogonal or slanting with respect to the direction of charged particle transportation along the channel.

8. A device according to claim 1, wherein additional DC voltages, and/or quasi-static voltages, and/or AC voltages, and/or pulsed voltages, and/or RF voltages are applied to the electrodes, the voltages providing control of the motion of the charged particles inside local zones of capture of charged particles.

9. A device according to claim 1, wherein additional DC voltages, and/or quasi-static voltages, and/or AC voltages, and/or pulsed voltages, and/or RF voltages are applied to the electrodes, the voltages providing additional potential or pseudopotential barriers, and/or potential or pseudopotential wells along the channel, at least at one point of the path within the said channel at least within some interval of time.

10. A device according to claim 1, wherein a supply voltage is applied to the electrodes, the frequency of which voltage varies at least within some interval of time.

11. A device according to claim 1, wherein for at least a portion of the device, the profile of the channel varies along the length of the channel.

12. A device according to claim 1 used in the structure of a cell for fragmentation of ions wherein packets of charged particles, consisting of positively and negatively charged particles are transmitted simultaneously.

13. A device according to claim 12 having an inlet intermediate device configured to combine two or more sources for mixing of ion beams.

14. A cell for fragmentation of ions, the cell comprising a device according to claim 1, wherein in use the high-frequency electric field within the device causes confinement of the ions.

15. A mass spectrometer comprising a device or cell according to claim 1.

16. A method of using a device according to claim 1 for compression of a beam of the charged particles in the course of transportation.

17. A method of using a device according to claim 1 as a fragmentation cell for fragmentation of ions.

18. A device according to claim 1, wherein the charged particles are transported with a lowered effective temperature by cooling the buffer gas, and the device is configured to transport the charged particles in a cooled state to the low pressure region of the channel in which the pressure is less than 5×

10<sup>−

3</sup> mbar.

19. A device according to claim 3, wherein the low pressure region of the channel is an extraction region, wherein the device is adapted to provide extraction of charged particles from the extraction region in a direction orthogonal or slanting with respect to the direction of charged particle transportation along the channel.

20. A device according to claim 1, wherein the supply voltages are high-frequency voltages of rectangular form created by alternately switching the supply voltages provided to the electrodes between two or more discrete DC levels;

wherein the series of electrodes comprises M groups of electrodes, each of the M groups having N electrodes where N is an integer number, wherein N supply voltages are connected individually to a respective one of the N electrodes in each of the M groups, and wherein the N supply voltages are modulated by means of a common digital controller so as to cause the at least two pseudopotential maxima to travel along said channel for transportation.