System and method of evaluating a subject with an ingestible capsule
First Claim
1. A method for determining a capsule transit time in the gastrointestinal tract comprising:
- recording sensor measurements from an ingested capsule comprising at least one sensor, wherein said at least one sensor is selected from a pH sensor, a pressure sensor and a temperature sensor, as said capsule passes through said gastrointestinal tract, wherein said sensor measurements are related to a parameter of said gastrointestinal tract;
transmitting said measurements to a processor, and using said processor to;
condition said sensor measurements to provide sensor data, the sensor data including at least a pH data, a pressure data and/or a temperature data;
establish a baseline body temperature by determining an average body temperature of the temperature data;
define a physical swallow of the capsule as a pH minimum located between a beginning of the pH data and a boundary point, the boundary point being a maximum pH value located in pH data after a potential stomach entry point, the potential stomach entry point being a pH data point corresponding to a temperature data point at or above the baseline body temperature;
plot said sensor data on a display as a function of time to produce a plot representing the gastrointestinal tract parameter;
provide a suggested marker on said plot at a location identifying a gastrointestinal transition time;
receive input from a user in response to a query regarding the location of the suggested marker on said plot;
set the suggested marker on said plot at a location as a function of said input; and
determine a capsule transit time in said gastrointestinal tract as a function of the location of said suggested marker as set on said plot.
7 Assignments
0 Petitions
Accused Products
Abstract
A computerized method of analyzing measurements obtained from the gastrointestinal tract of subject comprising the steps of providing an ingestible capsule (20) having a sensor (22, 23, 24) for measuring a parameter of the gastrointestinal tract of a subject, having a subject ingest (118) the capsule, recording (130) measurements from the sensor as the capsule passes through the gastrointestinal tract of the subject, transmitting (131, 122) the measurements to a processor (31), conditioning (132) the measurements to provide data as a function of a time interval, plotting (133) the data on a display (32), providing a query (205, 216, 234), on the display, receiving input (207a or 207b, 218a or 218b, 237a or 237b) from a user in response to the query, setting a marker (50-53) on the plot (40) at a location as a function of the input, and determining (238) a capsule transit time for a selected portion of the gastrointestinal tract as a function of the location of the marker.
-
Citations
66 Claims
-
1. A method for determining a capsule transit time in the gastrointestinal tract comprising:
-
recording sensor measurements from an ingested capsule comprising at least one sensor, wherein said at least one sensor is selected from a pH sensor, a pressure sensor and a temperature sensor, as said capsule passes through said gastrointestinal tract, wherein said sensor measurements are related to a parameter of said gastrointestinal tract; transmitting said measurements to a processor, and using said processor to; condition said sensor measurements to provide sensor data, the sensor data including at least a pH data, a pressure data and/or a temperature data; establish a baseline body temperature by determining an average body temperature of the temperature data; define a physical swallow of the capsule as a pH minimum located between a beginning of the pH data and a boundary point, the boundary point being a maximum pH value located in pH data after a potential stomach entry point, the potential stomach entry point being a pH data point corresponding to a temperature data point at or above the baseline body temperature; plot said sensor data on a display as a function of time to produce a plot representing the gastrointestinal tract parameter; provide a suggested marker on said plot at a location identifying a gastrointestinal transition time; receive input from a user in response to a query regarding the location of the suggested marker on said plot; set the suggested marker on said plot at a location as a function of said input; and determine a capsule transit time in said gastrointestinal tract as a function of the location of said suggested marker as set on said plot. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
-
25. A non-transitory computer-readable medium encoded with computer-executable instructions for performing a method comprising:
-
receiving measurements related to a gastrointestinal tract parameter of a subject recorded by at least one sensor, wherein said sensor is selected from a pH sensor, a pressure sensor and a temperature sensor, on a capsule ingested by said subject; conditioning said measurements to provide sensor data, the sensor data including at least a pH data, a pressure data and/or a temperature data; establishing a baseline body temperature by determining an average body temperature of the temperature data; defining a physical swallow of the capsule as a pH minimum located between a beginning of the pH data and a boundary point, the boundary point being a maximum pH value located in pH data after a potential stomach entry point, the potential stomach entry point being a pH data point corresponding to a temperature data point at or above the baseline body temperature; plotting said sensor data on a display as a function of time to produce a plot representing the gastrointestinal tract parameter; providing a suggested marker on said plot at a location identifying a gastrointestinal transition time; receiving, via an input device, input from a user in response to a query regarding the location of the suggested marker on said plot; setting the suggested marker on said plot at a location as a function of said input; and determining a capsule transit time in said gastrointestinal tract as a function of the location of said suggested marker as set on said plot. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
-
-
46. A system for analyzing measurements obtained from the gastrointestinal tract of a subject comprising:
-
an ingestible capsule having at least one sensor, wherein said at least one sensor is selected from a pH sensor, a pressure sensor and a temperature sensor, for recording measurements as said capsule passes through at least a portion of said subject'"'"'s gastrointestinal tract, said measurements are related to a parameter of the gastrointestinal tract; a receiver adapted to receive said measurements when transmitted from said capsule; a processor adapted to communicate with said receiver; a display in communication with said processor; an input device in communication with said processor; said processor programmed to; receive said measurements; condition said measurements to provide sensor data, the sensor data including at least a pH data, a pressure data and/or a temperature data; establish a baseline body temperature by determining an average body temperature of the temperature data; define a physical swallow of the capsule as a pH minimum located between a beginning of the pH data and a boundary point, the boundary point being a maximum pH value located in pH data after a potential stomach entry point, the potential stomach entry point being a pH data point corresponding to a temperature data point at or above the baseline body temperature; plot said sensor data on said display as a function of time to produce a plot representing the gastrointestinal tract parameter; provide a suggested marker on said plot at a location identifying a gastrointestinal transition time; receive input from said input device in response to a query regarding the location of the suggested marker on said plot; set the suggested marker on said plot at a location as a function of said input; and determine a capsule transit time in said gastrointestinal tract as a function of the location of said suggested marker as set on said plot. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
-
Specification