Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery
First Claim
1. A method for delivering Pramlintide to a patient in need thereof, said method comprising:
- providing a solid Pramlintide dosage shaped as a tissue penetrating member;
penetrating the solid dosage Pramlintide into an intestinal wall after oral ingestion, wherein Pramlintide is released into the blood stream from the solid dosage Pramlintide in the intestinal wall.
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Accused Products
Abstract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
205 Citations
26 Claims
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1. A method for delivering Pramlintide to a patient in need thereof, said method comprising:
- providing a solid Pramlintide dosage shaped as a tissue penetrating member;
penetrating the solid dosage Pramlintide into an intestinal wall after oral ingestion, wherein Pramlintide is released into the blood stream from the solid dosage Pramlintide in the intestinal wall. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- providing a solid Pramlintide dosage shaped as a tissue penetrating member;
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24. A method for delivering Pramlintide to a patient in need thereof, said method comprising:
- providing a Pramlintide dosage within a swallowable capsule having at least one tissue penetrating member having a lumen;
delivering the Pramlintide dosage into a wall of the small intestine from the capsule via the tissue penetrating member lumen and an application of force on the Pramlintide dosage, the delivery of the Pramlintide being effectuated responsive to a condition unique to the small intestine, and wherein the Pramlintide is released into the blood stream from the dosage of Pramlintide in the wall of the small intestine. - View Dependent Claims (25, 26)
- providing a Pramlintide dosage within a swallowable capsule having at least one tissue penetrating member having a lumen;
Specification