Pharmaceutical composition for preventing or treating cancer

• US 9,539,236 B2
• Filed: 06/01/2015
• Issued: 01/10/2017
• Est. Priority Date: 06/14/2013
• Status: Expired due to Fees

• Current Assignee: Medicinal Bio-convergence Research Center
• Original Assignee: Medicinal Bio-convergence Research Center
• Inventors: Kim, Sunghoon, Kwon, Nam Hoon, Kim, Dae Gyu
• Primary Examiner(s): JEAN-LOUIS, SAMIRA JM
• Application Number:
  US14/727,146
• Publication Number:
  US 20150258060A1
• Time in Patent Office: 589 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/395 having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: C07D 273/01 having one nitrogen atom

Abstract

Exemplary embodiments relate to a novel anticancer composition including a compound represented by chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient:

Claims

1. A pharmaceutical composition, comprising a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient in an effective amount to treat a subject in need of lung cancer treatment, and

wherein Chemical Formula 1 is as follows:

3. The pharmaceutical composition of claim 1, wherein the amount sufficient to treat the subject in need of lung cancer treatment is 0.1 to 1000 milligrams per day.

4. The pharmaceutical composition of claim 1, wherein the amount sufficient to treat the subject in need of lung cancer treatment is 1 to 500 milligrams per day.

5. The pharmaceutical composition of claim 1, wherein the subject in need is a mammal.

6. The pharmaceutical composition of claim 1, wherein the mammal is a human.

2. A method for treating lung cancer, the method comprising administrating an effective amount of a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof to a subject in need of lung cancer treatment, wherein Chemical Formula 1 is as follows:

7. A pharmaceutical formulation, comprising:

a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient in an effective amount to treat a subject in need of lung cancer treatment, and

wherein Chemical Formula 1 is as follows;

8. The pharmaceutical formulation of claim 7, further comprising lactose.

9. The pharmaceutical formulation of claim 8, wherein:

the pharmaceutical formulation is in the form of a powder,

the compound represented by Chemical Formula 1 is in an amount of 2 grams, and

the lactose is in an amount of 1 gram.

10. The pharmaceutical formulation of claim 8, further comprising cornstarch and magnesium stearate.

11. The pharmaceutical formulation of claim 10, wherein:

the compound represented by Chemical Formula 1 is in an amount of 100 milligrams,

the cornstarch is in an amount of 100 milligrams,

the lactose is in an amount of 100 milligrams, and

the magnesium stearate is in an amount of 2 milligrams.

12. The pharmaceutical formulation of claim 10, wherein the pharmaceutical formulation is in the form of a tablet or a capsule.

13. The pharmaceutical formulation of claim 8, further comprising glycerin and xylitol.

14. The pharmaceutical formulation of claim 13, wherein:

the pharmaceutical formulation is in the form of a pill,

the compound represented by Chemical Formula 1 is in an amount of 1 gram,

the lactose is in an amount of 1.5 grams,

the glycerin is in an amount of 1 gram, and

xylitol is in an amount of 0.5 grams.

15. The pharmaceutical formulation of claim 7, further comprising a soybean extract, glucose, and starch.

16. The pharmaceutical formulation of claim 15, wherein:

the pharmaceutical formulation is in the form of granules,

the compound represented by Chemical Formula 1 is in an amount of 150 milligrams,

the soybean extract is in an amount of 50 milligrams,

the glucose is in an amount of 200 milligrams, and

starch is in an amount of 600 milligrams.