Serum albumin binding molecules
First Claim
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1. A nucleic acid encoding a polypeptide comprising a fibronectin type III tenth (10Fn3) domain, wherein the 10Fn3 domain binds to domain 1 or 2 of human serum albumin with a KD of 1 μ
- M or less, and wherein the 10Fn3 domain comprises a modified amino acid sequence in one or more of the BC, DE and FG loops relative to the wild-type human 10Fn3 domain (SEQ ID NO;
1), and wherein the polypeptide comprises an amino acid sequence at least 75% identical to an amino acid sequence selected from SEQ ID NOs;
4, 8, 12, 16, 20, and 24-44.
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Abstract
The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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Citations
19 Claims
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1. A nucleic acid encoding a polypeptide comprising a fibronectin type III tenth (10Fn3) domain, wherein the 10Fn3 domain binds to domain 1 or 2 of human serum albumin with a KD of 1 μ
- M or less, and wherein the 10Fn3 domain comprises a modified amino acid sequence in one or more of the BC, DE and FG loops relative to the wild-type human 10Fn3 domain (SEQ ID NO;
1), and wherein the polypeptide comprises an amino acid sequence at least 75% identical to an amino acid sequence selected from SEQ ID NOs;
4, 8, 12, 16, 20, and 24-44. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- M or less, and wherein the 10Fn3 domain comprises a modified amino acid sequence in one or more of the BC, DE and FG loops relative to the wild-type human 10Fn3 domain (SEQ ID NO;
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16. A nucleic acid encoding a fusion polypeptide comprising a fibronectin type III tenth (10Fn3) domain and a heterologous protein, wherein the 10Fn3 domain binds to human serum albumin with a KD of 1 μ
- M or less and comprises an amino acid sequence at least 75% identical to an amino acid sequence selected from the group consisting of SEQ ID NOs;
4, 8, 12, 16, 20, and 24-44. - View Dependent Claims (17, 18, 19)
- M or less and comprises an amino acid sequence at least 75% identical to an amino acid sequence selected from the group consisting of SEQ ID NOs;
Specification