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Anti-PCSK9 antibodies with pH-dependent binding characteristics

  • US 9,540,449 B2
  • Filed: 08/12/2013
  • Issued: 01/10/2017
  • Est. Priority Date: 08/13/2012
  • Status: Active Grant
First Claim
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1. An isolated antibody or antigen-binding fragment thereof that binds human proprotein convertase subtilisin/kexin type 9 (PCSK9), wherein the acidic/neutral KD ratio for the antibody or antigen-binding fragment binding to PCSK9 at 25°

  • C. is greater than about 12.5 as determined by surface plasmon resonance;

    wherein the antibody or antigen-binding fragment thereof comprises 3 heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) and 3 light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3),wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO;

    220;

    wherein the HCDR2 comprises the amino acid sequence of SEQ ID NO;

    222;

    wherein the HCDR3 comprises the amino acid sequence selected from the group consisting of SEQ ID NOs;

    224 and 788;

    wherein the LCDR1 comprises the amino acid sequence of SEQ ID NO;

    802;

    wherein the LCDR2 comprises the amino acid sequence of SEQ ID NO;

    230; and

    wherein the LCDR3 comprises the amino acid sequence of SEQ ID NO;

    232.

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