Systems and methods for cardiomyocyte conduction speed mapping

• US 9,545,203 B2
• Filed: 06/25/2015
• Issued: 01/17/2017
• Est. Priority Date: 06/05/2014
• Status: Active Grant

• Current Assignee: Guangren Chen
• Original Assignee: Guangren Chen
• Inventors: Chen, Guangren, Yao, Lingling
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US14/749,696
• Publication Number:
  US 20150351650A1
• Time in Patent Office: 572 Days
• Field of Search: 600/516, 600/517, 600/523
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/339 Displays specially adapted therefor
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots

Abstract

Systems and methods are provided to display discrete conduction timing values of layers of the ventricles. Electrical impulses are detected using two or more electrodes placed proximate to a beating heart and are converted to an ECG waveform for each heartbeat of the beating heart. One or more subwaveforms within Q, R, S, and T waveforms of the ECG waveform for each heartbeat or in an interval between the Q, R, S, and T waveforms are detected that represent the depolarization or repolarization of anatomically distinct layers of the ventricles of the beating heart. A conduction timing value is calculated for each of the one or more subwaveforms for each electrode of the two or more electrodes for each heartbeat of the beating heart. At least one conduction timing value is displayed for at least one subwaveform for each electrode for at least one heartbeat of the beating heart.

Claims

1. A noninvasive electrocardiography (ECG) system for detecting one or more subwaveforms within the Q, R, S, and T waveforms or in an interval between the Q, R, S, and T waveforms and displaying at least one conduction timing value for at least one subwaveform of the one or more subwaveforms, comprising:

two or more electrodes adapted to be located near a beating heart of a patient and attached to the skin of the patient that receive electrical impulses from the beating heart;

a detector that detects the electrical impulses from at least one pair of electrodes of the two or more electrodes and converts the electrical impulses to an ECG waveform for each heartbeat of the beating heart;

a signal processor that receives the ECG waveform for each heartbeat from the detector, detects one or more subwaveforms within Q, R, S, and T waveforms of the ECG waveform or in an interval between the Q, R, S, and T waveforms that represent the depolarization or repolarization of anatomically distinct layers of the ventricles of the beating heart, and calculates a conduction timing value for each of the one or more subwaveforms for each electrode of the two or more electrodes for each heartbeat of the beating heart; and

a display device that displays at least one conduction timing value for at least one subwaveform of the one or more subwaveforms for each electrode of the two or more electrodes for at least one heartbeat of the beating heart.

2. The ECG system of claim 1, wherein the at least one subwaveform represents depolarization of an anatomically distinct layer of the ventricles.

3. The ECG system of claim 2, wherein the display device displays the at least one timing value for the at least one subwaveform and a timing value for every other subwaveform of the one or more subwaveforms that represents a depolarization of an anatomically distinct layer of the ventricles.

4. The ECG system of claim 1, wherein the at least one subwaveform represents repolarization of an anatomically distinct layer of the ventricles.

5. The ECG system of claim 4, wherein the display device displays the at least one timing value for the at least one subwaveform and a timing value for every other subwaveform of the one or more subwaveforms that represents a repolarization of an anatomically distinct layer of the ventricles.

6. The ECG system of claim 1, wherein the two or more electrodes comprise 12 electrodes.

7. The ECG system of claim 6, wherein the 12 electrodes are positioned in both the transverse and frontal planes.

8. The ECG system of claim 1, wherein the display device further displays the ECG waveform for at least one heartbeat of the beating heart.

9. The ECG system of claim 1, wherein the two or more subwaveforms comprise 20 subwaveforms representing depolarization and repolarization of 10 layers of the ventricles.

10. The ECG system of claim 1, wherein the display device further displays near the at least one timing value a color and/or pattern.

11. The ECG system of claim 10, wherein the display device further displays a cross sectional diagram of showing muscle layers of a ventricles of a heart with a layer of the ventricles corresponding to the at least one timing value depicted in the color and/or pattern.

12. An invasive electrocardiography (ECG) system for detecting one or more subwaveforms within the Q, R, S, and T waveforms or in an interval between the Q, R, S, and T waveforms and displaying at least one conduction timing value for at least one subwaveform of the one or more subwaveforms, comprising:

two or more electrodes adapted to be placed directly on the surface of a beating heart of the patient that receive electrical impulses from the beating heart;

a detector that detects the electrical impulses from at least one pair of electrodes of the two or more electrodes and converts the electrical impulses to an ECG waveform for each heartbeat of the beating heart;

a signal processor that receives the ECG waveform for each heartbeat from the detector, detects one or more subwaveforms within Q, R, S, and T waveforms of the ECG waveform or in an interval between the Q, R, S, and T waveforms that represent the depolarization or repolarization of anatomically distinct layers of the ventricles of the beating heart, and calculates a conduction timing value for each of the one or more subwaveforms for each electrode of the two or more electrodes for each heartbeat of the beating heart; and

a display device that displays at least one conduction timing value for at least one subwaveform of the one or more subwaveforms for each electrode of the two or more electrodes for at least one heartbeat of the beating heart.

13. The ECG system of claim 12, wherein the at least one subwaveform represents depolarization of an anatomically distinct layer of the ventricles.

14. The ECG system of claim 13, wherein the display device displays the at least one timing value for the at least one subwaveform and a timing value for every other subwaveform of the one or more subwaveforms that represents a depolarization of an anatomically distinct layer of the ventricles.

15. The ECG system of claim 12, wherein the at least one subwaveform represents repolarization of an anatomically distinct layer of the ventricles.

16. The ECG system of claim 15, wherein the display device displays the at least one timing value for the at least one subwaveform and a timing value for every other subwaveform of the one or more subwaveforms that represents a repolarization of an anatomically distinct layer of the ventricles.

17. The ECG system of claim 12, wherein the two or more electrodes comprise 12 electrodes.

18. The ECG system of claim 17, wherein the 12 electrodes are positioned in both the transverse and frontal planes.

19. The ECG system of claim 12, wherein the display device further displays the ECG waveform for at least one heartbeat of the beating heart.

20. The ECG system of claim 12, wherein the two or more subwaveforms comprise 20 subwaveforms representing depolarization and repolarization of 10 layers of the ventricles.