Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
First Claim
1. A method comprisingusing an ultrasound contrast agent to enhance contrast in an echocardiographic ultrasound image of a subject, wherein the ultrasound contrast agent comprises1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL;
- sodium chloride;
glycerin, present in an amount of about 0.1 mL/mL;
propylene glycol, present in an amount of about 0.1 mL/mL;
water, andperfluoropropane.
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Abstract
The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
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Citations
1 Claim
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1. A method comprising
using an ultrasound contrast agent to enhance contrast in an echocardiographic ultrasound image of a subject, wherein the ultrasound contrast agent comprises 1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL; -
sodium chloride; glycerin, present in an amount of about 0.1 mL/mL; propylene glycol, present in an amount of about 0.1 mL/mL; water, and perfluoropropane.
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Specification