Ionizable cationic lipids
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Abstract
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
41 Citations
33 Claims
- 1. A compound having the structure:
- 3. A compound of having the structure:
- 10. A compound having the structure:
- 12. A compound having the structure:
- 16. A compound having the structure:
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20. A compound having the structure:
Specification