Synthesis of UDP-glucose:;-acylsphingosine glucosyl transferase inhibitors
First Claim
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1. A method of preparing an amine compound represented by the following structural formula:
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Abstract
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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3 Claims
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1. A method of preparing an amine compound represented by the following structural formula:
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2. The method of claim 1 wherein the amide reducing agent is lithium aluminum hydride.
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3. The method of claim 1 wherein the amide reducing agent is borane tetrahydrofuran.
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