Mobile hemolysis detection in whole blood samples
First Claim
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1. A system for measuring hemoglobin concentration in a whole blood sample within a short period of time after drawing said whole blood sample from a patient or subject, comprising:
- a containment apparatus having a substantially hollow interior defined by a plurality of sidewalls that are light impenetrable,said plurality of sidewalls includingleft and right sidewalls,a bottom sidewall,a top sidewall that is removable or openable to provide access into said substantially hollow interior of said containment apparatus from a top side of said containment apparatus,a front sidewall, anda rear sidewall or frame that is structured to receive an electronic mobile device having a camera function;
a cuvette stand disposed on said front sidewall within said interior of said containment apparatus, said cuvette stand configured to receive and hold a cuvette containing said whole blood sample in a position directly opposite from a camera lens of said mobile device;
a flash dispersing flange positioned along said rear sidewall corresponding to a flash of said camera function of said mobile device in order to scatter any light from said flash,wherein said mobile device includes a non-transitory computer medium that contains computer-executable instructions which when executed by a processor causes the processor causes the processor to perform the step ofreceiving an image of said whole blood sample from said camera function of said mobile device,detecting a color of a separated plasma component within said whole blood sample, andautomatically determining a hemoglobin concentration and a hemolysis level in said whole blood sample based on said detected color of said plasma component,wherein when said top sidewall is closed and said mobile device is inserted into said rear sidewall, external light cannot penetrate into said substantially hollow interior of said containment apparatus.
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Abstract
A system for hemolysis detection, where the system generally includes—individually or in combination—a containment apparatus for holding the blood sample and a software application for analyzing the blood sample. The containment apparatus houses the sample therein, and blocks out any light from penetrating the apparatus and reflecting off of the sample. In conjunction, the software application uses camera color for processing the color of the sample to determine the hemoglobin level in plasma based on the color.
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Citations
16 Claims
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1. A system for measuring hemoglobin concentration in a whole blood sample within a short period of time after drawing said whole blood sample from a patient or subject, comprising:
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a containment apparatus having a substantially hollow interior defined by a plurality of sidewalls that are light impenetrable, said plurality of sidewalls including left and right sidewalls, a bottom sidewall, a top sidewall that is removable or openable to provide access into said substantially hollow interior of said containment apparatus from a top side of said containment apparatus, a front sidewall, and a rear sidewall or frame that is structured to receive an electronic mobile device having a camera function; a cuvette stand disposed on said front sidewall within said interior of said containment apparatus, said cuvette stand configured to receive and hold a cuvette containing said whole blood sample in a position directly opposite from a camera lens of said mobile device; a flash dispersing flange positioned along said rear sidewall corresponding to a flash of said camera function of said mobile device in order to scatter any light from said flash, wherein said mobile device includes a non-transitory computer medium that contains computer-executable instructions which when executed by a processor causes the processor causes the processor to perform the step of receiving an image of said whole blood sample from said camera function of said mobile device, detecting a color of a separated plasma component within said whole blood sample, and automatically determining a hemoglobin concentration and a hemolysis level in said whole blood sample based on said detected color of said plasma component, wherein when said top sidewall is closed and said mobile device is inserted into said rear sidewall, external light cannot penetrate into said substantially hollow interior of said containment apparatus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of measuring hemoglobin concentration in a whole blood sample within a short period of time after drawing said whole blood sample from a patient or subject, comprising:
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providing a containment apparatus having a substantially hollow interior configured to enclose said whole blood sample, said containment apparatus having at least one (1) opening through which a mobile device can capture an image of said whole blood sample, said substantially hollow interior defined by a plurality of sidewalls that are light impenetrable, said plurality of sidewalls including left and right sidewalls, a bottom sidewall, a top sidewall that is removable or openable to provide access into said substantially hollow interior of said containment apparatus from a top side of said containment apparatus, a front sidewall, and a rear sidewall or frame that is structured to receive said mobile device having a camera function, positioning a flash dispersing flange along said rear sidewall corresponding to a flash of said camera function of said mobile device in order to scatter any light from said flash, providing on said mobile device a non-transitory computer medium that contains computer-executable instructions executed by a processor; positioning a lens of said mobile device through said opening in said containment apparatus, such that external light cannot penetrate into said substantially hollow interior of said containment apparatus; and capturing said image of said whole blood sample, said processor performing the steps of receiving said image of said whole blood sample from said mobile device, detecting a color of a separated plasma component within said whole blood sample, and automatically determining hemoglobin concentration and hemolysis level in said whole blood sample based on said detected color of said plasma component. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification