Polymer membranes for continuous analyte sensors
First Claim
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1. An implantable device for continuous measurement of an analyte concentration, the implantable device comprising:
- a sensor configured to generate a signal indicative of a concentration of an analyte in a host; and
a membrane located over the sensor, the membrane comprising a first domain configured to reduce a flux therethrough of the analyte, a second domain that comprises an enzyme, and a third domain configured to reduce passage therethrough of an interferent, the third domain comprising a plurality of alternating polyelectrolyte layers, wherein the device is configured to exhibit a selectivity for acetaminophen over hydrogen peroxide of less than about 0.005, wherein the selectivity is determined by dividing a sensitivity of the device for acetaminophen by a sensitivity of the device for hydrogen peroxide, wherein the acetaminophen sensitivity is determined in vitro by measuring the device'"'"'s current response versus concentrations of acetaminophen at 10 μ
M aqueous acetaminophen, 50 μ
M aqueous acetaminophen, and 100 μ
M aqueous acetaminophen, and then performing linear regression, and wherein the hydrogen peroxide sensitivity is determined in vitro by measuring the device'"'"'s current response versus concentrations of hydrogen peroxide at 1 μ
M aqueous hydrogen peroxide, 2 μ
M aqueous hydrogen peroxide, and 3 μ
M aqueous hydrogen peroxide, and then performing linear regression.
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents.
36 Citations
13 Claims
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1. An implantable device for continuous measurement of an analyte concentration, the implantable device comprising:
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a sensor configured to generate a signal indicative of a concentration of an analyte in a host; and a membrane located over the sensor, the membrane comprising a first domain configured to reduce a flux therethrough of the analyte, a second domain that comprises an enzyme, and a third domain configured to reduce passage therethrough of an interferent, the third domain comprising a plurality of alternating polyelectrolyte layers, wherein the device is configured to exhibit a selectivity for acetaminophen over hydrogen peroxide of less than about 0.005, wherein the selectivity is determined by dividing a sensitivity of the device for acetaminophen by a sensitivity of the device for hydrogen peroxide, wherein the acetaminophen sensitivity is determined in vitro by measuring the device'"'"'s current response versus concentrations of acetaminophen at 10 μ
M aqueous acetaminophen, 50 μ
M aqueous acetaminophen, and 100 μ
M aqueous acetaminophen, and then performing linear regression, and wherein the hydrogen peroxide sensitivity is determined in vitro by measuring the device'"'"'s current response versus concentrations of hydrogen peroxide at 1 μ
M aqueous hydrogen peroxide, 2 μ
M aqueous hydrogen peroxide, and 3 μ
M aqueous hydrogen peroxide, and then performing linear regression. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification