Polymer membranes for continuous analyte sensors
First Claim
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1. A device for continuous in vivo measurement of a glucose concentration, the device comprising:
- an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host;
an enzyme-containing membrane located over the sensor, wherein the enzyme-containing membrane comprises both hydrophilic and hydrophobic regions, and wherein the enzyme-containing membrane comprises;
an enzyme configured to catalyze a reaction that has glucose as a reactant; and
a polyurethane comprising a plurality of repeating hard segments and repeating soft segments, wherein a soft segment of the plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons; and
sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow produced by the sensor to generate sensor data indicative of glucose concentration.
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
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9 Claims
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1. A device for continuous in vivo measurement of a glucose concentration, the device comprising:
an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host; an enzyme-containing membrane located over the sensor, wherein the enzyme-containing membrane comprises both hydrophilic and hydrophobic regions, and wherein the enzyme-containing membrane comprises; an enzyme configured to catalyze a reaction that has glucose as a reactant; and a polyurethane comprising a plurality of repeating hard segments and repeating soft segments, wherein a soft segment of the plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons; and sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow produced by the sensor to generate sensor data indicative of glucose concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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