Oil and liquid silicone foamable carriers and formulations
First Claim
1. An essentially waterless composition in a container, comprising a carrier and a liquefied or compressed gas propellant, wherein the carrier comprises:
- a liquid oil;
about 0.5% to about 15% by weight of the carrier of a cyclic silicone;
at least one foam stabilizing agent comprising a co surfactant and/or a foam adjuvant or a surfactant comprising a fatty acid ester or a mixture of any two or more thereof; and
a minocycline or a doxycycline or both;
a solid wax or solid oil selected from a group consisting of a solid paraffin, a hydrogenated oil, a hydrogenated emollient, palmitic acid or mixtures of any two or more thereof;
wherein the ratio of the carrier to the propellant is 100;
3 to 100;
35;
wherein upon release of the composition from the container, a foam results that does not collapse immediately and is breakable on mechanical shear; and
wherein the minocycline or the doxycycline is stable for at least 3 weeks at 25°
C. in the essentially waterless composition.
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Accused Products
Abstract
A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
989 Citations
27 Claims
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1. An essentially waterless composition in a container, comprising a carrier and a liquefied or compressed gas propellant, wherein the carrier comprises:
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a liquid oil; about 0.5% to about 15% by weight of the carrier of a cyclic silicone; at least one foam stabilizing agent comprising a co surfactant and/or a foam adjuvant or a surfactant comprising a fatty acid ester or a mixture of any two or more thereof; and a minocycline or a doxycycline or both; a solid wax or solid oil selected from a group consisting of a solid paraffin, a hydrogenated oil, a hydrogenated emollient, palmitic acid or mixtures of any two or more thereof; wherein the ratio of the carrier to the propellant is 100;
3 to 100;
35;wherein upon release of the composition from the container, a foam results that does not collapse immediately and is breakable on mechanical shear; and
wherein the minocycline or the doxycycline is stable for at least 3 weeks at 25°
C. in the essentially waterless composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27)
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26. An essentially waterless composition in a container, comprising a carrier, wherein the carrier comprises:
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a liquid oil; about 0.5% to about 15% by weight of the carrier of a cyclic silicone; at least one foam stabilizing agent comprising a co surfactant and/or a foam adjuvant or a surfactant comprising a fatty acid ester or a mixture of any two or more thereof and a minocycline or a doxycycline or both; a solid wax or solid oil selected from a group consisting of a solid paraffin, a hydrogenated oil, a hydrogenated emollient, palmitic acid or mixtures of any two or more thereof; wherein the liquid oil is about 60% to about 95% by weight of the carrier; wherein the foam stabilizing agent is selected from the group consisting of about 0.1% to about 25% by weight of at least one surface-active agent alone or in combination with a foam adjuvant; and wherein the minocycline or the doxycycline is stable for at least 3 weeks at 25°
C. in the essentially waterless composition.
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Specification