Lipid-polymer hybrid particles
First Claim
Patent Images
1. A particle comprising:
- an aqueous core;
a first amphiphilic layer surrounding the aqueous core;
a polymeric matrix surrounding the first amphiphilic layer; and
one or more active agents, wherein at least one of the active agents is an immunostimulatory agent comprising a toll receptor (TLR) ligand ss/dsRNA, a polyI;
C polynucleotide, or a CpG polynucleotide.
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Abstract
A particle includes an aqueous core; a first amphiphilic layer surrounding the aqueous core; and a polymeric matrix surrounding the first amphiphilic layer.
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Citations
33 Claims
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1. A particle comprising:
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an aqueous core; a first amphiphilic layer surrounding the aqueous core; a polymeric matrix surrounding the first amphiphilic layer; and one or more active agents, wherein at least one of the active agents is an immunostimulatory agent comprising a toll receptor (TLR) ligand ss/dsRNA, a polyI;
C polynucleotide, or a CpG polynucleotide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 31, 32, 33)
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26. A particle comprising:
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an aqueous core; a first amphiphilic layer surrounding the aqueous core, wherein the first amphiphilic layer comprises 1,2-dimyristoleoyl-sn-glycero-3-ethylphosphocholine (EPC14;
1); anda polymeric matrix surrounding the first amphiphilic layer. - View Dependent Claims (27, 28, 29, 30)
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Specification