Medicament delivery apparatus

• US 9,550,050 B2
• Filed: 09/20/2007
• Issued: 01/24/2017
• Est. Priority Date: 09/25/2006
• Status: Active Grant

• Current Assignee: Biora Therapeutics Incorporated
• Original Assignee: Medimetrics Personalized Drug Delivery B.V.
• Inventors: Dijksman, Johan Frederik, Pierik, Anke, Rensen, Judith Margreet, Shimizu, Jeff, Zou, Hans, Pardoel, Michel, De Jongh, Frits Tobi
• Primary Examiner(s): GRAY, PHILLIP A
• Application Number:
  US12/442,408
• Publication Number:
  US 20100063486A1
• Time in Patent Office: 3,414 Days
• Field of Search: 6048901-8921, 604 65- 67, 604151-155, 604/132, 604/133
• US Class Current: 1/1
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.

Claims

1. An electronic capsule comprising:

a drive element comprising;

a drive element housing,

control electronics for operating the electronic capsule disposed in the drive element housing,

a drive unit disposed in the drive element housing,

a power source operatively associated with the electronic capsule, control electronics and drive unit disposed in the drive element housing, and

a drive element connector; and

a payload element comprising;

a payload element housing,

a sealed reservoir secured in the payload element housing and storing a substance,

one or more openings formed through the payload element housing to provide fluid communication between an inside of the payload element housing and an outside of the payload element housing for releasing the substance contained in the reservoir from the capsule, and

a payload element connector adapted to engage the drive element connector,

wherein an engagement of the drive element connector with the payload element connector secures the drive element to the payload element and positions the drive unit for operable communication with the reservoir, thereby making the electronic capsule operable and specific.

2. The capsule of claim 1, wherein drive element connector and the payload element connector form a click-type lock.

3. The capsule of claim 1, wherein the drive element connector is an anchoring recess.

4. The capsule of claim 1, wherein the payload element connector is a locking pin.

5. The capsule of claim 1, wherein the housing of the payload element further comprises at least one vent opening positioned to allow communication between the reservoir and the outside of the capsule.

6. The capsule of claim 5, further comprising a semi-permeable membrane which overlies the vent opening and allows for air transport therethrough.

7. The capsule of claim 1, wherein the payload element further comprises a gasketing insert for providing a seal around the reservoir.

8. The capsule of claim 7, wherein the gasketing insert further has weakened areas.

9. The capsule of claim 1, wherein the payload element has two or more separate reservoirs, and wherein the separate reservoirs are each separated by a membrane.

10. The capsule of claim 9, wherein the membrane is collapsible.

11. The capsule of claim 1, further comprising a second discrete payload element having a reservoir for storing a substance, a first connector for attaching the second discrete payload to the drive element and a second connector for attaching the second discrete payload to a first discrete payload.

12. The capsule of claim 1, further comprising sensors for determining the location of the capsule.

13. The capsule of claim 1, further comprising a communication means for enabling the electronic capsule to send and receive commands.

14. The capsule of claim 1, wherein the drive element further comprises a separate and discrete power source housing element, the housing element housing the power source, thereby separating the power source from the other elements of drive element.

20. The capsule of claim 6, wherein the membrane impedes the flow of fluids therethrough.

21. The electronic capsule of claim 1, wherein the reservoir comprises a deformable wall.

22. The electronic capsule of claim 21, wherein the deformable wall is secured to an inside surface of the payload element housing.

23. The electronic capsule of claim 1, wherein the payload element further comprises one or more removable seals, each of the removable seals sealing one of the one or more openings.

24. The electronic capsule of claim 23, wherein the engagement of the drive element connector with the payload element connector removes the one or more removable seals from sealing engagement with the respective one of the one or more openings.

25. The electronic capsule of claim 1, wherein the reservoir comprises at least one weakened area, and wherein the engagement of the drive element connector with the payload element connector breaks the reservoir at the one or more weakened areas to create an opening in the reservoir through which the substance can exit the reservoir.

26. The electronic capsule of claim 25, wherein the at least one weakened area is aligned with at least one of the one or more openings.

15. An electronic capsule comprising:

a discrete drive element comprising;

a drive element housing,

control electronics for operating the electronic capsule disposed in the drive element housing,

a drive unit disposed in the drive element housing,

a drive element first locking mechanism, and

a drive element second locking mechanism;

a discrete power element comprising;

a power element housing,

a power source disposed in the power element housing for powering the electronic capsule and operatively associated with the control electronics and the drive unit, and

a power element locking mechanism; and

a discrete payload element comprising;

a payload element housing,

a sealed reservoir secured in the payload element housing and storing a substance,

one or more openings in the payload element housing in fluid communication with the reservoir for releasing a substance contained in the reservoir from the capsule, and

a payload element locking mechanism for engaging the drive element second locking mechanism,

wherein engagement of the power element locking mechanism with the drive element first locking mechanism secures the power source housing element to the drive element, and engagement of the drive element second locking mechanism with the payload element locking mechanism secures the drive element to the payload element, said engagement making the electronic capsule operable and specific.

16. The capsule of claim 15, wherein the housing of the payload element further comprises at least one vent opening.

17. The capsule of claim 15, further comprising a communication means for enabling the electronic capsule to send and receive commands.

18. The capsule of claim 15, wherein the payload element has two or more separate reservoirs, and wherein the separate reservoirs are each separated by a collapsible membrane.

19. The capsule of claim 15, further comprising a second discrete payload element having a reservoir for storing a substance, a first locking mechanism for attaching the second discrete payload to the drive element and a second locking mechanism for attaching the second discrete payload to a first discrete payload element.