Medical devices having activated surfaces

• US 9,555,154 B2
• Filed: 02/19/2010
• Issued: 01/31/2017
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Belcheva, Nadya, Abuzaina, Ferass, Elachchabi, Amin, Kapiamba, Mbiya, Hadba, Ahmed Robert
• Primary Examiner(s): Buckley, Audrea
• Application Number:
  US13/202,357
• Publication Number:
  US 20120041546A1
• Time in Patent Office: 2,538 Days
• US Class Current: 1/1
• CPC Class Codes: A61L 17/10 containing macromolecular materials
• CPC Class Codes: A61L 17/105 Polyesters not covered by A61L17/12
• CPC Class Codes: A61L 17/12 Homopolymers or copolymers of glycolic acid or lactic acid
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08J 7/123 Treatment by wave energy or particle radiation C08J7/18 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]
• CPC Class Codes: Y10T 428/3154 Of fluorinated addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31725 Of polyamide
• CPC Class Codes: Y10T 428/31855 Of addition polymer from unsaturated monomers

Abstract

Implantable biocompatible polymeric medical devices include a substrate with a plasma-modified surface which is subsequently modified to include click reactive members.

Claims

1. A medical device having a plasma-treated surface that is functionalized with a click reactive member to provide an activated surface on the medical device.

2. The medical device of claim 1, wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, gut, copolymers and combinations thereof.

3. The method of claim 1, wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, nylons, polyamides, polyurethanes, silicones, ultra high molecular weight polyethylene, polybutesters, polyaryletherketone, copolymers and combinations thereof.

4. The medical device of claim 1, wherein the click reactive member is selected from the group consisting of thiols, azides, alkynes and alkenes.

5. The medical device of claim 1, wherein the click reactive member comprises a thiol.

6. The medical device claim 1, wherein the click reactive member comprises an azide.

7. The medical device of claim 1, wherein the click reactive member comprises an alkyne.

8. The medical device of claim 1, wherein the click reactive member comprises an alkene.

9. The medical device of claim 1, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.

10. A method of preparing a medical device having an activated surface, the method comprising:

plasma treating at least a portion of a surface of an absorbable polymeric medical device; and

attaching one or more click reactive members to the plasma treated surface of the absorbable polymeric medical device.

11. The method according to claim 10, wherein the plasma treating provides reactive members on the surface of the medical device.

12. The method according to claim 10, wherein the plasma treating provides a coating on the device, the coating including reactive members on the surface of the medical device.

13. The method according to claim 10, wherein the medical device comprises a natural polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, gut, copolymers and combinations thereof.

14. The method according to claim 10, wherein the click reactive member is selected from the group consisting of thiols, azides, alkynes and alkenes.

15. The method according to claim 10, wherein the click reactive member comprises a thiol.

16. The method according to claim 10, wherein the click reactive member comprises an azide.

17. The method according to claim 10, wherein the click reactive member comprises an alkyne.

18. The method according to claim 10, wherein the click reactive member comprises an alkene.

19. The method according to claim 10, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.

20. The method according to claim 10, wherein the medical device comprises a synthetic polymer.

21. The method according to claim 10 wherein the plasma treatment lasts less than 5 minutes.

22. The method according to claim 10 further comprising the step of combining the absorbable polymeric medical device with a drug functionalized with one or more complimentary click reactive members to covalently bond the drug to the surface of the absorbable polymeric substrate for drug delivery.