System for delivery of medication in treatment of disorders of the pelvis

• US 9,555,168 B2
• Filed: 04/18/2016
• Issued: 01/31/2017
• Est. Priority Date: 03/27/2003
• Status: Active Grant

• Current Assignee: Coloplast A/S
• Original Assignee: Coloplast A/S
• Inventors: Browning, James
• Primary Examiner(s): Palenik, Jeffrey T
• Application Number:
  US15/131,043
• Publication Number:
  US 20160228620A1
• Time in Patent Office: 288 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 6/02 for use by males A61F6/20 takes precedence
• CPC Class Codes: A61F 6/06 for use by females A61F6/20 takes precedence
• CPC Class Codes: A61F 6/142 Wirelike structures, e.g. loops, rings, spirals
• CPC Class Codes: A61K 9/0036 Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
• CPC Class Codes: A61K 9/0039 Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 31/028 Other inorganic materials not covered by A61L31/022 - A61L31/026
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 31/007 Injectors for solid bodies, e.g. suppositories
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

A system for delivery of medication in treatment of disorders of the pelvis is disclosed. The system includes a medicament applied to an implantable device and an insertion tool. The implantable device has a first end opposite from a second end, with the first end of the implantable device insertable into tissue within the pelvis. A retrieval string is coupled to the second end of the implantable device. The insertion tool includes a shaft extending between a proximal end and a distal end, with a handle coupled to the proximal end of the insertion tool and the distal end of the insertion tool is adapted to couple with the implantable device. The handle includes a notch adapted to releasably secure the retrieval string.

Claims

1. A system for delivery of medication in treatment of disorders of the pelvis, the system comprising:

an implantable device including a first end opposite from a second end, with the first end of the implantable device insertable into tissue within the pelvis;

a medicament applied to the implantable device;

a retrieval string coupled to the second end of the implantable device; and

an insertion tool including a shaft extending between a proximal end and a distal end, with a handle coupled to the proximal end of the insertion tool and the distal end of the insertion tool adapted to couple with the implantable device;

wherein the handle includes a notch adapted to releasably secure the retrieval string.

2. The system of claim 1, wherein the first end of the implantable device has a first diameter and the second end of the implantable device has a head having a second diameter, with the second diameter larger than the first diameter.

3. The system of claim 1, wherein the distal end of the insertion tool is insertable into the implantable device.

4. The system of claim 1, wherein the distal end of the insertion tool forms a protrusion that is insertable into a depression on the second end of the implantable device.

5. The system of claim 1, wherein the second end of the implantable device has a head forming a depression, and the distal end of the insertion tool is insertable into the depression of the head of the implantable device.

6. The system of claim 1, wherein the medicament includes an anti-cholinergic medicament.

7. The system of claim 1, wherein the medicament includes a calcium antagonist.

8. The system of claim 1, wherein the medicament includes an agent for radiotherapy.

9. The system of claim 1, wherein the medicament is selected to treat oestrogen dependent proliferative disorders of the pelvis.

10. The system of claim 1, wherein the medicament is provided to treat an over active bladder with a controlled delivery of the medicament over a duration of time.

11. The system of claim 1, wherein the medicament is selected from the group consisting of progestins, GnRH agonists/antagonists, NSAIDs, COX-II inhibitors, combined oral contraceptives, Danazol, smooth muscle relaxants, and aromatase inhibitors.

12. The system of claim 1, wherein the implantable device is absorbable.

13. The system of claim 1, wherein the medicament is selected from the group consisting of anti-infectives, antimicrobials, prebiotics, probiotics, acidifiers, antivirals, antibiotics, anti-allergenics, anti-inflammatories, anti-fungals, anticholinesterases, and chemotherapeutic agents.

14. The system of claim 1, further comprising:

a carrier applied to the implantable device;

wherein the carrier is one of a hydrogel, a silicone based material, an elastomer, a proteinaceous material, a polyethylene glycol material, a carbohydrate material, and a polysaccharide carbohydrate material that provides controlled delivery of the medicament over a duration of time.