Transdermal drug delivery method and system

• US 9,555,226 B2
• Filed: 06/22/2015
• Issued: 01/31/2017
• Est. Priority Date: 10/27/2003
• Status: Active Grant

• Current Assignee: Morningside Venture Investments Ltd. (Morningside Group Ltd.)
• Original Assignee: Chrono Therapeutics Inc.
• Inventors: Imanidis, Georgios, Dipierro, Guy, Van De Venn, Hans Werner, Zumbrunn, Werner
• Primary Examiner(s): GHALI, ISIS A D
• Application Number:
  US14/746,689
• Publication Number:
  US 20150283366A1
• Time in Patent Office: 589 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/04 Nitro compounds
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/465 Nicotine; Derivatives thereof
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/3337 Controlling, regulating pressure or flow by means of a valve by-passing a pump
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.

Claims

1. A method for transdermal administration of an active substance dissolved in a solvent, the method comprising:

placing a dispensing device in contact with skin, the dispensing device comprising a reservoir, a skin interface and a solvent recovery element;

dispensing a first portion of the active substance dissolved in the solvent from the reservoir to the skin interface;

delivering the active substance through the interface to the skin; and

removing solvent from the skin interface and trapping the solvent within the solvent recovery element to control delivery of the active substance through the interface to the skin.

2. The method of claim 1, wherein the active substance and solvent are dispensed from the reservoir to the skin interlace in response to a control signal.

3. The method of claim 1, further comprising adhesively attaching the skin interface to the skin.

4. The method of claim 1, wherein the solvent is removed from the skin interface by the solvent recovery element while the skin interface is in contact with the skin.

5. The method of claim 1, wherein the removing step comprises passing solvent through a separation layer between the skin interface and the solvent recovery element.

6. The method of claim 1, wherein the removing step comprises evaporating solvent.

7. The method of claim 1, further comprising controlling volume and frequency of active substance and solvent dispensed in the dispensing step.

8. The method of claim 1, wherein the dispensing step comprises dispensing the active substance and solvent in a non-constant manner.

9. The method of claim 1, wherein the dispensing step comprises dispensing the active substance and solvent according to a circadian rhythm of a user.

10. The method of claim 1, further comprising ceasing removing solvent after ceasing dispensing to terminate delivery of the active substance through the interface to the skin.

11. The method or claim 1, further comprising diffusing the active substance from the skin interface into the skin.

12. The method of claim 1, wherein the removing step comprises moving solvent through a non-wettable but vapor permeable material.