Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions

• US 9,557,154 B2
• Filed: 05/24/2011
• Issued: 01/31/2017
• Est. Priority Date: 05/25/2010
• Status: Active Grant

• Current Assignee: Boston University, The General Hospital Corporation (Mass General Brigham, Inc.), Trustees of Boston University
• Original Assignee: Boston University, The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Tearney, Guillermo J., Bouma, Brett Eugene, Yoo, Hongki, Shishkov, Milen, Gardecki, Joseph, Shubochkin, Roman, Morse, Theodore, Jaffer, Farouc Amin
• Primary Examiner(s): REMALY, MARK DONALD
• Application Number:
  US13/114,845
• Publication Number:
  US 20120101374A1
• Time in Patent Office: 2,079 Days
• Field of Search: 600/407, 600476-480
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01B 9/02029 Combination with non-interferometric systems, i.e. for measuring the object
• CPC Class Codes: G01B 9/0205 of probe head
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence
• CPC Class Codes: G01N 21/6456 Spatial resolved fluorescence measurements; Imaging
• CPC Class Codes: G01N 21/65 Raman scattering
• CPC Class Codes: G01N 2201/0866 Use of GRIN elements

Abstract

Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Claims

1. An arrangement for providing at least one electro-magnetic radiation to an anatomical structure, comprising:

at least one optical core and at least one cladding at least partially surrounding the at least one core with a region therebetween, wherein the region has an index that is different from indices of the at least one optical core and the at least one cladding;

at least one optical apparatus which includes a lens configuration that is configured to direct the at least one radiation via at least one of the at least one optical core or the at least one cladding to the anatomical structure; and

at least one optical system which is configured to receive, through the lens configuration, at least two radiations from the anatomical structure via at least one of the at least one optical core or the at least one cladding.

2. The arrangement according to claim 1, wherein the at least one apparatus includes an optical coherence tomography system.

3. The arrangement according to claim 1, further comprising a computer system which is configured to determine information regarding the anatomical structure using the at least one radiation with a procedure based on a fluorescence modality.

4. The arrangement according to claim 3, wherein the fluorescence modality is at least one of exogenous or endogenous.

5. The arrangement according to claim 1, further comprising a computer system which is configured to determine information regarding the anatomical structure using the at least one radiation with a procedure based on an optical frequency domain interferometry (OFDI) modality, a spectral domain optical coherence tomography (SD-OCT) modality, a time domain optical coherence tomography (TD-OCT) modality, a near-infrared modality, a Raman modality, a photo acoustics modality, a confocal modality, an ablation modality, or a lifetime modality.

6. The arrangement according to claim 5, wherein the near-infrared modality is at least one of a near-infrared spectroscopy modality or a near-infrared fluorescence modality.

7. The arrangement according to claim 1, wherein the at least one apparatus includes at least one of a probe, a catheter, an eye box or an endoscope.

8. The arrangement according to claim 1, further comprising at least one additional cladding at least partially surrounding the at least one cladding.

9. The arrangement according to claim 8, further comprising at least one further cladding at least partially surrounding the at least one additional cladding.

10. The arrangement according to claim 1, wherein the at least one radiation comprises at least two radiations, and wherein a first one of the radiations is a back-reflected light, and a second one of the radiations is a fluorescence light.

11. The arrangement according to claim 1, further comprising at least one rotation devices which is configured to rotate the at least one optical apparatus.

12. The arrangement according to claim 1, further comprising a cross-talk barrier.

13. An arrangement for providing at least two electro-magnetic radiations to an anatomical structure, comprising:

at least one optical core and at least one cladding at least partially surrounding the at least one optical core,

at least one optical apparatus that includes a lens configuration which is configured to (i) direct at least one of the radiations via the at least one optical core, and (ii) direct at least another one of the radiations via the at least one cladding to the anatomical structure; and

at least one optical system configured to, through the lens configuration, (i) receive and obtain a first radiation from the anatomical structure via the at least one core, and (ii) receive and obtain a second radiation from the anatomical structure via the at least one cladding.

14. The arrangement according to claim 13, wherein the first radiation is a microstructural light and the second radiation is a fluorescence light.

15. The arrangement according to claim 13, wherein the optical system receives and obtains the first radiation using a procedures which is one of optical frequency domain interferometry (OFDI) modality, spectral domain optical coherence tomography (SD-OCT) modality or time domain optical coherence tomography (TD-OCT) modality, wherein the optical system receives and obtains the second radiation using a procedure based on a near-infrared modality, a Raman modality, a photo acoustics modality, a confocal modality, an ablation modality or a lifetime modality.

16. The arrangement according to claim 15, wherein the near-infrared modality is at least one of an near-infrared spectroscopy modality or a near-infrared fluorescence modality.

17. The arrangement according to claim 13, wherein the at least one apparatus includes at least one of a probe, a catheter, an eye box or an endoscope.

18. The arrangement according to claim 13, further comprising at least one additional cladding at least partially surrounding the at least one cladding.

19. The arrangement according to claim 18, further comprising at least one further cladding at least partially surrounding the at least one additional cladding.

20. The arrangement according to claim 13, wherein the at least one of the radiations is back-reflected light, and the at least another one of the radiations is a fluorescence light.

21. The arrangement according to claim 13, further comprising a cross-talk barrier.

22. The arrangement according to claim 13, further comprising at least one rotation device which is configured to rotate the at least one optical apparatus.