Luminescence based noninvasive remote parameter sensor and sensing method

• US 9,560,974 B2
• Filed: 06/29/2012
• Issued: 02/07/2017
• Est. Priority Date: 06/29/2011
• Status: Expired due to Fees

• Current Assignee: University of Maryland Baltimore County (University of Maryland)
• Original Assignee: University of Maryland Baltimore County (University of Maryland)
• Inventors: Falk, Steven M, Tolosa, Leah, Lam, Hung, Kostov, Yordan, Rao, Govind
• Primary Examiner(s): CERIONI, DANIEL LEE
• Application Number:
  US13/539,067
• Publication Number:
  US 20130079661A1
• Time in Patent Office: 1,684 Days
• Field of Search: 600/549
• US Class Current: 1/1
• CPC Class Codes: A61B 2503/045 Newborns, e.g. premature baby monitoring
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/74 Details of notification to user or communication with user or patient indicating measured values G01D7/00; user input means input or output arrangements for computers G06F3/00

Abstract

A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.

Claims

1. A noninvasive remote sensor for measuring temperature, comprising:

at least a first gel;

a first type of fluorophore embedded in at least the first gel, wherein the first type of fluorophore emits first emission light via luminescence in response to first excitation light, wherein the luminescence of the first type of fluorophore varies as a function of temperature;

a second type of fluorophore embedded in at least the first gel that also contains the first type of fluorophore, wherein the second type of fluorophore emits second emission light via luminescence in response to second excitation light, wherein the luminescence of the second type of fluorophore varies as a function of temperature;

a light detector positioned to detect the first and second emission light, wherein the light detector generates at least one detector signal corresponding to the first and second emission light, wherein at least one characteristic of the at least one detector signal represents both at least one parameter of the first emission light of the first emission light and at least one parameter of the first emission light; and

a process controller in communication with the light detector, wherein the process controller determines a temperature value of an object in contact with at least the first gel based on the at least one characteristic of the at least one detector signal, wherein the temperature value is dependent on the at least one characteristic of the at least one detector signal such that a change in the at least one characteristic of the at least one detector signal will result in a change in the determined temperature value.

2. The sensor of claim 1, wherein the at least one characteristic comprises a ratio F1/F2, where F1 corresponds to an intensity of light emitted from the first type of fluorophore and F2 corresponds to an intensity of light emitted from the second type of fluorophore.

3. The sensor of claim 1, wherein the at least one characteristic corresponds to a decay time difference between the first and second emission light when the first and second excitation light is intensity modulated.

4. The sensor of claim 1, wherein the first and second types of fluorophores comprise fluorophores that are excitable by visible light.

5. The sensor of claim 4, wherein the first type of fluorophore comprises ruthenium(II) tris(1, 10-phenanthroline).

6. The sensor of claim 4, wherein the second type of fluorophore comprises 8-aminopyrene-1,3,6-trisulfonic acid.

7. The sensor of claim 1, wherein at least the first gel is non-toxic and hypoallergenic.

8. The sensor of claim 1, wherein at least the first gel has anti-bacterial properties.

9. The sensor of claim 1, wherein at least the first gel comprises a hydrogel matrix.

10. The sensor of claim 9, wherein at least the first gel comprises chitosan or glyceryl polyacrylate.

11. The sensor of claim 3, wherein the light detector comprises a CCD camera.

12. The sensor of claim 11, wherein the process controller utilizes lock-in imaging to measure the decay time difference.

13. A noninvasive remote sensor for measuring temperature, comprising:

a first;

a first type of fluorophore embedded in the first hydrogel, wherein the first type of fluorophore emits first emission light via luminescence in response to first excitation light, wherein the luminescence of the hydrogel first type of fluorophore varies as a function of temperature;

a second hydrogel;

a second type of fluorophore embedded in the second hydrogel, wherein the second type of fluorophore emits second emission light via luminescence in response to second excitation light, wherein the luminescence of the second type of fluorophore varies as a function of temperature;

at least one light detector positioned to detect the first and second emission light, wherein the light detector generates at least one detector signal corresponding to the first and second emission light, wherein at least one characteristic of the at least one detector signal represents both at least one parameter of the first emission light and at least one parameter of the second emission light; and

a process controller in communication with the at least one light detector, wherein the process controller determines a temperature value of an object in contact with both the first and second hydrogels based on the at least one characteristic of the at least one detector signal, wherein the determined temperature value is dependent on the at least one characteristic of the at least one detector signal such that a change in the at least one characteristic of the at least one detector signal will result in a change in the determined temperature value.

14. The sensor of claim 13, wherein the at least one characteristic comprises a ratio F1/F2, where F1 corresponds to an intensity of light emitted from the first type of fluorophore and F2 corresponds to an intensity of light emitted from the second type of fluorophore.

15. The sensor of claim 13, wherein the first and second types of fluorophores comprise fluorophores that are excitable by visible light.

16. The sensor of claim 15, wherein the first type of fluorophore comprises ruthenium(II) tris(1, 10-phenanthroline).

17. The sensor of claim 15, wherein the second type of fluorophore comprises 8-aminopyrene-1,3,6-trisulfonic acid.

18. The sensor of claim 13, wherein the first and second hydrogels each comprise chitosan or glyceryl polyacrylate.