Fluid handling cassette system for body fluid analyzer

• US 9,561,001 B2
• Filed: 01/06/2011
• Issued: 02/07/2017
• Est. Priority Date: 10/06/2005
• Status: Active Grant

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Keenan, Richard, Chiou, Jeff, Gable, Jennifer, Li, Ken, Tong, Roger, Recknor, Mike, Braig, James R.
• Primary Examiner(s): Sasaki, Shogo
• Application Number:
  US12/986,112
• Publication Number:
  US 20110218411A1
• Time in Patent Office: 2,224 Days
• Field of Search: 702/19, 702/22, 702/31, 436/180, 422/105, 422/81, 422/509, 422/516, 422/521, 137/247.15, 137/624.27, 137/455, 604/131
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q

Abstract

A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.

Claims

1. A fluid handling system for use in bodily fluid analysis, said system comprising:

a first fluid handling module configured to interface with a main instrument having an optical sensor, said first fluid handling module having;

a first frame or housing;

a fluid handling network supported by the first frame or housing, said fluid handling network including an infusate passage configured to couple to an infusate reservoir, wherein the fluid handling network includes a patient connection passageway that is configured to deliver fluid from the infusate reservoir to a patient and that is configured to draw a sample of bodily fluid from the patient; and

a fluid pressure member configured to engage a pressure member actuator of the main instrument to produce pressure to move the sample of bodily fluid within the fluid handling network; and

a second fluid handling module configured to interface with said main instrument, said second fluid handling module having a second frame or housing, one or more fluid passageways supported by the second frame or housing, and at least one sample cell that is accessible via said one or more fluid passageways, wherein said second fluid handling module further comprises a fluid component separator accessible via said one or more fluid passageways, wherein said fluid component separator comprises a centrifuge rotor, wherein the fluid component separator is configured to separate a fluid sample into a plurality of components and position one or more of the components in the sample cell so that the optical sensor can measure an analyte in the one or more components;

wherein said first and second modules are configured to interconnect and provide fluid communication between said fluid handling network and said sample cell.

2. The system of claim 1, wherein said fluid pressure member comprises a pump.

3. The system of claim 1, wherein said fluid pressure member comprises a syringe pump body.

4. The system of claim 1, wherein said fluid pressure member comprises a portion of said fluid handling network that is configured to engage a roller pump actuator.

5. The system of claim 4, wherein said fluid pressure member comprises a fluid passage that extends across an opening in the first frame or housing, which facilitates engagement of said fluid passage with said roller pump actuator.

6. The system of claim 1, wherein said first fluid handling module further comprises a cleanser fluid source accessible via said first fluid handling network.

7. The system of claim 6, wherein said first fluid handling module further comprises a cleanser fluid pressure member suitable for moving fluid from said cleanser fluid source.

8. The system of claim 1, wherein said first fluid handling module further comprises an anticoagulant fluid source accessible via said first fluid handling network.

9. The system of claim 8, wherein said first fluid handling module further comprises an anticoagulant fluid pressure member suitable for moving fluid from said anticoagulant fluid source.

10. The system of claim 1, wherein said first and second modules are interconnected and said first fluid handling network is in fluid communication with the sample cell.

11. The fluid handling system of claim 1, wherein the fluid component separator comprises a centrifuge.

12. The fluid handling system of claim 1, wherein the first frame or housing is separate from the second frame or housing such that one of the first fluid handling module and the second fluid handling module can be removed from the main instrument while the other of the first fluid handling module and the second fluid handling module remains connected to the main instrument.

13. The fluid handling system of claim 1, wherein the first fluid handing module is removably attachable to the second fluid handling module.

14. The fluid handling system of claim 1, wherein the first frame or housing comprises a frame, and wherein the second frame or housing comprises a housing.

15. The fluid handling system of claim 14, wherein the housing is removably attachable to the frame.

16. The fluid handling system of claim 1, the first frame or housing comprises openings configured to align with valves and/or sensors on the main instrument such that the valves and/or sensors on the main instrument can engage fluid passageways of the fluid handling network.

17. The fluid handling system of claim 16, wherein one or more of the openings can be configured to align with one more syringe pump actuators on the main instrument such that the one or more syringe pump actuators can engage one or more syringe pump bodies on the first fluid handling module.

18. The fluid handling system of claim 1, wherein the first fluid handling module comprises an infusion fluid pressure member suitable for moving fluid within said infusate passage.

19. The fluid handling system of claim 1, wherein the system has an engaged configuration in which the fluid handling network is in fluid communication with the at least one sample cell and a disengaged configuration in which the fluid handling network is not in fluid communication with the at least one sample cell.