Pharmaceutical composition containing a block copolymer bound to a boronic acid compound

• US 9,561,284 B2
• Filed: 04/02/2012
• Issued: 02/07/2017
• Est. Priority Date: 03/31/2011
• Status: Expired due to Fees

• Current Assignee: NanoCarrier Co., Ltd.
• Original Assignee: NanoCarrier Co., Ltd.
• Inventors: Tanaka, Ryosuke, Saito, Hiroyuki, Kobayashi, Katsutoshi, Harada, Mitsunori, Kato, Yasuki
• Primary Examiner(s): Barham, Bethany
• Assistant Examiner(s): Cao, Ping
• Application Number:
  US14/008,181
• Publication Number:
  US 20140017192A1
• Time in Patent Office: 1,772 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/69 Boron compounds
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/645 Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

A pharmaceutical composition includes a block copolymer having a hydrophilic segment, a hydrophobic segment, and a boronic acid compound bound to a side chain of the hydrophobic segment via a linker moiety that includes a heterocyclic structure. The heterocyclic structure contains a cyclic skeleton that includes a boron atom of the boronic acid compound, one or two atom(s) X bound to the boron atom and selected from an oxygen atom and a nitrogen atom, and one or two carbon atom(s) (respectively) bound to the atom(s) X. The block copolymer further includes at least one organic group bound to the carbon atom(s). The organic group(s) contain(s) an aromatic group or cyclic alkyl group that sterically protects a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atom(s) X.

Claims

1. A pharmaceutical composition comprising a block copolymer having the following chemical structure:

2. The pharmaceutical composition according to claim 1 having the following chemical structure:

3. A pharmaceutical composition having the following chemical structure: