Fluid delivery systems, devices, and methods for delivery of hazardous fluids

• US 9,561,344 B2
• Filed: 04/13/2015
• Issued: 02/07/2017
• Est. Priority Date: 04/08/2003
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Uber, Arthur E. III, Hirschman, Alan D., Griffiths, David M., Trombley, Frederick W. III, Reilly, David M.
• Primary Examiner(s): Mendez, Manuel
• Application Number:
  US14/684,900
• Publication Number:
  US 20150231363A1
• Time in Patent Office: 666 Days
• Field of Search: 604/523, 604/534, 604/284, 604/264, 604/131, 604 65- 67, 604/82
• US Class Current: 1/1
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 2202/049 Toxic
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/44 having means for cooling or heating the devices or media
• CPC Class Codes: A61N 5/1001 using radiation sources introduced into or applied onto the body; brachytherapy

Abstract

A catheter including an outer conduit and an inner conduit positioned within the outer conduit, the inner conduit having a smaller diameter that that of the outer conduit. A volume between the outer conduit and the inner conduit define a first lumen which may deliver a first fluid to a patient, and an inside diameter of the inner conduit defines a second lumen which may deliver a second fluid to the patient such that the fluid flow of the first fluid and the second fluid exiting the catheter has a flow profile where the first fluid surrounds the second fluid and the second fluid is prevented from contact with inner walls of a blood vessel of the patient in a vicinity of a tip of the catheter.

Claims

1. A catheter, comprising:

an outer conduit; and

an inner conduit positioned within the outer conduit and having a diameter smaller than a diameter of the outer conduit,

wherein a volume between the outer conduit and the inner conduit define a first lumen adapted to deliver a first fluid to a patient, and an inside diameter of the inner conduit define a second lumen adapted to deliver a second fluid to the patient such that a fluid flow of the first fluid and the second fluid exiting the catheter has a flow profile where the first fluid surrounds the second fluid and the second fluid is prevented from contact with inner walls of a blood vessel of the patient in a vicinity of a tip of the catheter,

wherein the first fluid is saline and the second fluid is a hazardous pharmaceutical.

2. The catheter of claim 1, wherein the inner conduit ends rearward of the outer conduit.

3. The catheter of claim 1, wherein the second fluid is an antitumor chemotherapy pharmaceutical.

4. A method for delivering a hazardous pharmaceutical comprising:

providing a catheter comprising an outer conduit, and an inner conduit positioned within the outer conduit and having a diameter smaller than a diameter of the outer conduit, wherein a volume between the outer conduit and the inner conduit define a first lumen adapted to deliver a first fluid to a patient, and an inside diameter of the inner conduit define a second lumen adapted to deliver a second fluid to the patient;

flowing the first fluid through the first lumen; and

after a predetermined time, flowing the second fluid through the second lumen,

wherein the fluid flow of the first fluid and the second fluid exiting the catheter has a flow profile where the first fluid surrounds the second fluid such that the second fluid is prevented from contact with inner walls of a blood vessel of the patient in a vicinity of a tip of the catheter.

5. The method of claim 4, wherein the first fluid is saline and the second fluid is a hazardous pharmaceutical.

6. The method of claim 4, further comprising reducing a flow rate of the first fluid by an amount equal to a flow rate of the second fluid at the predetermined time, such that a flow rate of the fluid exiting the catheter remains constant.

7. The method of claim 6, further comprising reducing the flow rate of the second fluid to zero after sufficient amount of the second fluid has been administered;

and increasing the flow rate of the first fluid so that the flow rate of the fluid exiting the catheter remains constant.

8. The method of claim 4, wherein delivery of the second fluid is continuous until all of the second fluid is delivered.

9. The method of claim 4, wherein delivery of the second fluid is periodic and separated by delivery of only the first fluid between pulses of the second fluid.