Conditional electrical stimulation

• US 9,561,366 B2
• Filed: 09/20/2011
• Issued: 02/07/2017
• Est. Priority Date: 03/27/2009
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Wei, Xuan K., Bonde, Eric H.
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US13/237,216
• Publication Number:
  US 20120010680A1
• Time in Patent Office: 1,967 Days
• Field of Search: 607/40
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36062 Spinal stimulation
• CPC Class Codes: A61N 1/36107 Sexual dysfunction stimulating genital organs A61N1/36007
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

In general, the disclosure describes techniques for providing conditional electrical stimulation to a patient for pelvic health. An implantable medical device (IMD) may adjust the delivery cycle of the electrical stimulation applied to a patient in response to receiving a delivery cycle parameter associated with one or more of the following: a time in a time schedule, a control device output from a control device, and physiological information from a physiological information sensing device. As an example, the IMD may monitor a status of one or more inputs of the IMD and adjust the delivery cycle of the electrical stimulation applied to the patient based on the status of the input(s).

Claims

1. A device comprising:

means for applying, with a first delivery cycle, a first plurality of electrical stimulation pulse trains from an electrical stimulation device to a patient, wherein each electrical stimulation pulse train of the plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the first delivery cycle of the first plurality of electrical stimulation pulse trains is a first ratio of a first time duration during which the electrical stimulation pulse train of the first plurality of stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the first plurality of stimulation pulse trains; and

means for receiving an indication of a voiding or defecation event, wherein the indication comprises at least one of a user input or physiological information from a physiological information sensing device;

means for applying, with a second delivery cycle and in response to the indication of the voiding or defecation event, a second plurality of electrical stimulation pulse trains from the electrical stimulation device to the patient, wherein each electrical stimulation pulse train of the second plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the second delivery cycle of the second plurality of electrical stimulation pulse trains is a second ratio of a first time duration during which the electrical stimulation pulse train of the second plurality of stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the second plurality of stimulation pulse trains and is less than the first delivery cycle; and

means for automatically increasing, gradually over at least three electrical stimulation pulse trains, a delivery cycle of the electrical stimulation pulse trains from the second delivery cycle to a third delivery cycle, wherein each electrical stimulation pulse train of the at least three electrical stimulation pulse trains comprises a plurality of pulses, and wherein the third delivery cycle is a third ratio of a first time duration during which the electrical stimulation pulse train of the at least three stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the at least three pulse trains and is greater than the second delivery cycle.

2. The device of claim 1, wherein the electrical stimulation pulse trains are applied to at least one of a sacral nerve, a pudendal nerve, or a dorsal genital nerve to alleviate a pelvic floor disorder of the patient.

3. The device of claim 1, wherein a pulse duty cycle is substantially unchanged between a first electrical stimulation pulse train of the at least three electrical stimulation pulse strains and a last electrical stimulation pulse train of the at least three electrical stimulation pulse trains.

4. A method comprising:

applying, with a first delivery cycle, a first plurality of electrical stimulation pulse trains from an electrical stimulation device to a patient, wherein each electrical stimulation pulse train of the plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the first delivery cycle of the first plurality of electrical stimulation pulse trains is a first ratio of a first time duration during which the electrical stimulation pulse train of the first plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the first plurality of electrical stimulation pulse trains;

receiving an indication of a voiding or defecation event, wherein the indication comprises at least one of a user input or physiological information from a physiological information sensing device;

applying, with a second delivery cycle and in response to the indication of the voiding or defecation event, a second plurality of electrical stimulation pulse trains from the electrical stimulation device to the patient, wherein each electrical stimulation pulse train of the second plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the second delivery cycle of the second plurality of electrical stimulation pulse trains is a second ratio of a first time duration during which the electrical stimulation pulse train of the second plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the second plurality of electrical stimulation pulse trains and is less than the first delivery cycle; and

automatically increasing, gradually over at least three electrical stimulation pulse trains, a delivery cycle of the electrical stimulation pulse trains from the second delivery cycle to a third delivery cycle, wherein each electrical stimulation pulse train of the at least three electrical stimulation pulse trains comprises a plurality of pulses, and wherein the third delivery cycle of the electrical stimulation pulse train is a third ratio of a first time duration during which the electrical stimulation pulse train of the at least three electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains at least three electrical stimulation pulse trains and is greater than the second delivery cycle.

5. The method of claim 4, wherein the electrical stimulation pulse trains are applied to at least one of a sacral nerve, a pudendal nerve, or a dorsal genital nerve of the patient to alleviate a pelvic floor disorder of the patient.

6. The method of claim 4, wherein a pulse duty cycle is substantially unchanged between a first electrical stimulation pulse train of the at least three electrical stimulation pulse strains and a last electrical stimulation pulse train of the at least three electrical stimulation pulse trains.

7. A system comprising:

a therapy delivery circuit configured to apply a plurality of electrical stimulation pulse trains from an electrical stimulation device to a patient, wherein each electrical stimulation pulse train of the plurality of electrical stimulation pulse trains comprises a series of pulses; and

a processor configured to;

cause the therapy delivery circuit to apply, with a first delivery cycle, a first plurality of electrical stimulation pulse trains to the patient, wherein the first delivery cycle of the first plurality of electrical stimulation pulse trains is a first ratio of a first time duration during which the electrical stimulation pulse train of the first plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the first plurality of electrical stimulation pulse trains;

receive an indication of a voiding or defecation event, wherein the indication comprises at least one of a user input or physiological information from a physiological information sensing device;

cause the therapy delivery circuit to apply, with a second delivery cycle and in response to the indication of the voiding or defecation event, a second plurality of electrical stimulation pulse trains to the patient, wherein the second delivery cycle of the second plurality of electrical stimulation pulse trains is a second ratio of a first time duration during which the electrical stimulation pulse train of the second plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the second plurality of electrical stimulation pulse trains and is less than the first delivery cycle; and

automatically increase, gradually over at least three electrical stimulation pulse trains, a delivery cycle of the electrical stimulation pulse trains from the second delivery cycle to a third delivery cycle, wherein the third delivery cycle is a ratio of a first time duration during which the electrical stimulation pulse train of the at least three electrical simulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the at least three electrical stimulation pulse trains and is greater than the second delivery cycle.

8. The system of claim 7, wherein the therapy delivery circuit is configured to apply the electrical stimulation pulse trains from the electrical stimulation device to at least one of a sacral nerve, a pudendal nerve, or a dorsal genital nerve of the patient to alleviate a pelvic floor disorder of the patient.

9. The system of claim 7, further comprising an implantable medical device, wherein the implantable medical device comprises the processor and the therapy delivery circuit.

10. The system of claim 7, further comprising an implantable medical device and a programmer, wherein the implantable medical device comprises the therapy delivery circuit and the programmer comprises the processor.

11. The system of claim 7, wherein a pulse duty cycle is substantially unchanged between a first electrical stimulation pulse train of the at least three electrical stimulation pulse strains and a last electrical stimulation pulse train of the at least three electrical stimulation pulse trains.

12. A non-transitory computer readable medium comprising instructions that cause a programmable processor to:

cause a therapy delivery circuit to apply, with a first delivery cycle, a first plurality of electrical stimulation pulse trains from an electrical stimulation device to a patient, wherein each electrical stimulation pulse train of the plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the first delivery cycle of the first plurality of electrical stimulation pulse trains is a first ratio of a first time duration during which the electrical stimulation pulse train of the first plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the first plurality of electrical stimulation pulse trains;

receive an indication of a voiding or defecation event, wherein the indication comprises at least one of a user input or physiological information from a physiological information sensing device;

cause a therapy delivery circuit to apply, with a second delivery cycle and in response to the indication of the voiding or defecation event, a second plurality of electrical stimulation pulse trains from the electrical stimulation device to the patient, wherein each electrical stimulation pulse train of the second plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the second delivery cycle of the second plurality of electrical stimulation pulse trains is a second ratio of a first time duration during which the electrical stimulation pulse train of the second plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the second plurality of electrical stimulation pulse trains and is less than the first delivery cycle; and

automatically increase, gradually over at least three electrical stimulation pulse trains, a delivery cycle of the electrical stimulation pulse trains from the second delivery cycle to a third delivery cycle, wherein each electrical stimulation pulse train of the at least three electrical stimulation pulse trains comprises a plurality of pulses, and wherein the third delivery cycle of the electrical stimulation pulse train is a third ratio of a first time duration during which the electrical stimulation pulse train of the at least three electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains and is greater than the second delivery cycle of the at least three electrical stimulation pulse trains.

13. The non-transitory computer readable medium of claim 12, wherein a pulse duty cycle is substantially unchanged between a first electrical stimulation pulse train of the at least three electrical stimulation pulse strains and a last electrical stimulation pulse train of the at least three electrical stimulation pulse trains.