Systems and methods for treating autonomic instability and medical conditions associated therewith

• US 9,561,370 B2
• Filed: 09/09/2015
• Issued: 02/07/2017
• Est. Priority Date: 03/11/2013
• Status: Active Grant

• Current Assignee: Ohio State Innovation Foundation (Ohio State University)
• Original Assignee: Ohio State Innovation Foundation (Ohio State University)
• Inventors: Rezai, Ali R., Agrawal, Punit
• Primary Examiner(s): Manuel, George
• Application Number:
  US14/848,966
• Publication Number:
  US 20160045727A1
• Time in Patent Office: 517 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36062 Spinal stimulation
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

One aspect of the present disclosure relates to a closed-loop therapy system for treating autonomic instability or a medical condition associated therewith in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing component can be configured to detect at least one physiological parameter associated with autonomic instability or a medical condition associated therewith. The delivery component can be configured for implantation on or about an autonomic nervous tissue target or a spinal nervous tissue target. The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component to modulate activity at the autonomic nervous tissue target or a spinal nervous tissue target and effectively treat autonomic instability or a medical condition associated therewith.

Claims

1. A closed-loop therapy delivery system for treating autonomic instability or a medical condition associated therewith in a subject, the therapy delivery system comprising:

a sensing component configured to detect at least one physiological parameter associated with autonomic instability or the medical condition associated therewith;

a delivery component configured for implantation on or about an autonomic nervous tissue target or a spinal nervous tissue target; and

a controller configured to automatically coordinate operation of the sensing and delivery components;

wherein the controller is programmed to deliver an electrical signal to the delivery component to modulate activity at the autonomic nervous tissue target or a spinal nervous tissue target and effectively treat the autonomic instability or the medical condition associated therewith;

wherein the controller is programmed to deliver an electrical signal having a frequency of about 10,000 Hz to about 25,000 Hz.

2. The system of claim 1, wherein the delivered electrical signal substantially blocks activity at the autonomic nervous tissue target or a spinal nervous tissue target.

3. The system of claim 1, wherein the at least one physiological parameter includes a chemical moiety or an electrical activity.

4. The system of claim 1, wherein the autonomic nervous tissue target is a ganglion of the sympathetic nervous system (SNS).

5. The system of claim 4, wherein the ganglion of the SNS is a cervical ganglion, a cervicothoracic ganglion, or a thoracic ganglion.

6. The system of claim 5, wherein the cervical ganglion is an upper, middle, or lower cervical ganglion.

7. The system of claim 1, wherein the spinal nervous tissue target is one of a cervical spinal cord segment, a thoracic spinal cord segment, a lumbar spinal cord segment, a sacral spinal cord segment, or spinal nervous tissue associated therewith.

8. A method for treating autonomic instability or a medical condition associated therewith in a subject, the method comprising the steps of:

placing a therapy delivery device into electrical communication with an autonomic nervous tissue target or a spinal nervous tissue target associated with autonomic instability or the medical condition associated therewith; and

activating the therapy delivery device to deliver an electrical signal to the autonomic nervous tissue target or a spinal nervous tissue target to effectively treat autonomic instability or the medical condition associated therewith in the subject;

wherein the electrical signal has a frequency of about 10,000 Hz to about 25,000 Hz.

9. The method of claim 8, further comprising the steps of:

sensing at least one physiological parameter associated with autonomic instability or the medical condition associated therewith;

generating a sensor signal based on the at least one physiological parameter; and

activating the therapy delivery device to adjust application of the electrical signal to the autonomic nervous tissue target or a spinal nervous tissue target in response to the sensor signal to treat autonomic instability or the medical condition associated therewith.

10. The method of claim 9, wherein the at least one physiological parameter includes a chemical moiety or an electrical activity.

11. The method of claim 8, wherein the delivered therapy delivery substantially decreases sympathetic activity at the autonomic nervous tissue target or a spinal nervous tissue target.

12. The method of claim 8, wherein the autonomic nervous tissue target is a ganglion of the SNS.

13. The method of claim 12, wherein the ganglion of the SNS is a cervical ganglion, a cervicothoracic ganglion, or a thoracic ganglion.

14. The method of claim 13, wherein the cervical ganglion is an upper, middle, or lower cervical ganglion.

15. The method of claim 8, wherein the spinal nervous tissue target is one of a cervical spinal cord segment, a thoracic spinal cord segment, a lumbar spinal cord segment, a sacral spinal cord segment, or spinal nervous tissue associated therewith.

16. The method of claim 8, wherein the medical condition associated with autonomic instability is a neurological condition.