Oral therapy of necrotizing enterocolitis
First Claim
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1. An infant nutritional formula comprising a therapeutically effective amount of a CpG-ODN comprising 5′
- TCGTCGTTTTGTCGTTCCTGACGTT 3′
(SEQ ID NO;
9), further comprising nutrients selected from the group consisting of proteins, lipids, carbohydrates, electrolytes, and vitamins.
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Abstract
The present invention relates to methods of treating or reducing the risk of necrotizing enterocolitis (NEC) in an infant comprising orally administering an effective amount of a CpG-ODN. It is based, at least in part, on the results of experiments in which orally administered CpG-ODNs were observed to reduce the histopathology and markers of inflammation in a murine model for NEC. The present invention further provides for oral formulations of CpG-ODN for administration to infants.
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Citations
6 Claims
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1. An infant nutritional formula comprising a therapeutically effective amount of a CpG-ODN comprising 5′
- TCGTCGTTTTGTCGTTCCTGACGTT 3′
(SEQ ID NO;
9), further comprising nutrients selected from the group consisting of proteins, lipids, carbohydrates, electrolytes, and vitamins. - View Dependent Claims (2, 3, 4, 5, 6)
- TCGTCGTTTTGTCGTTCCTGACGTT 3′
Specification