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Boron-containing small molecules

DC CAFC
  • US 9,566,290 B2
  • Filed: 04/20/2016
  • Issued: 02/14/2017
  • Est. Priority Date: 02/16/2005
  • Status: Active Grant
First Claim
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1. A method of treating a human having onychomycosis of a toenail caused by Trichophyton rubrum or Trichophyton mentagrophytes, the method comprising:

  • topically administering to the toenail a pharmaceutical composition comprising an amount of 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt thereof, effective to inhibit an aminoacyl tRNA synthetase in the Trichophyton rubrum or Trichophyton mentagrophytes.

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