Notch inhibition in the prevention of vein graft failure
First Claim
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1. A method of treating a patient to reduce the risk of vein graft failure, comprising administering to said patient a therapeutically effective amount of a compound selected from the group consisting of:
- an anti-Delta-like 4 antibody and a Delta-like 4 (Dll4) siRNA, wherein said compound inhibits a Notch signaling pathway.
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Abstract
The present invention is directed to methods of treating a patient to prevent vein graft failure by administering a compound that inhibits the Notch signaling pathway.
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20 Claims
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1. A method of treating a patient to reduce the risk of vein graft failure, comprising administering to said patient a therapeutically effective amount of a compound selected from the group consisting of:
- an anti-Delta-like 4 antibody and a Delta-like 4 (Dll4) siRNA, wherein said compound inhibits a Notch signaling pathway.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating a patient subsequent to the implantation of a vein graft, comprising administering to said patient a compound selected from the group consisting of:
- an anti-Delta-like 4 antibody and a Delta-like 4 (Dll4) siRNA, wherein said compound is administered at a dose of 0.01 to 500 mg/kg and inhibits a Notch signaling pathway.
- View Dependent Claims (19, 20)
Specification