Simulation and control system and method using contact, pressure waves and factor controls for cell regeneration, tissue closure and related applications

• US 9,569,566 B2
• Filed: 12/12/2012
• Issued: 02/14/2017
• Est. Priority Date: 12/12/2011
• Status: Active Grant

• Current Assignee: ZAM Research, LLC
• Original Assignee: ZAM Research, LLC
• Inventors: Zamierowski, David S., Bubb, Stephen K., Billings, Wade M., Hildebrandt, Patrick A., Tobaben, Eric J.
• Primary Examiner(s): NEGIN, RUSSELL SCOTT
• Application Number:
  US13/712,872
• Publication Number:
  US 20130151223A1
• Time in Patent Office: 1,525 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: G06F 30/20 Design optimisation, verification or simulation optimisation, verification or simulation of circuit designs G06F30/30
• CPC Class Codes: G16B 5/00 ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A description of a device and method of use are provided for a containment chamber, accompanying sensing and monitoring instrumentation, and method of creation of a physical force wave that would be capable of mimicking physiologic waves such as pulse pressure, muscle contraction, peristalsis, acoustic waves and other desired waves to be studied. This device allows for the use of various biologic or biologically comparable fluids—alone or in combination—that would allow for the analysis of the passage of these waves through these media. Singularly, this device also allows for the manipulation of the external constraints that mimic the containment of that media in vivo. This allows for the analysis of the effects on the nature of the wave, its reflections, potential augmentation or dampening that occur in conjunction with various selected external and internal (baffle) constraints that mimic those found in nature or in therapeutic interventions.

Claims

1. A system for simulating an in vivo cellular interaction in a simulated therapy zone and measuring sensed simulated cellular response characteristics for output via an operator interface, which system comprises:

a medium material including a characteristic simulating an in vivo characteristic, said medium material including an interior forming said simulated therapy zone and an outer surface;

a container enclosing said medium material outer surface and configured for receiving and containing said medium material;

said container including external constraints configured to mimic in vivo conditions and for application to said medium material;

an energy source adapted for exerting a pressure gradient via simulation onto the cell and measuring a response of the cell to the simulated pressure gradient;

a simulated cell manipulating factor source connected to the medium material and the energy source;

said simulated cell manipulating factor source being chosen from the group comprising;

fluid pressure gradient;

a pressure differential manifold in the simulated therapy zone;

an inflow line fluidically connecting the factor source to the pressure differential manifold;

an outflow line from the pressure differential manifold;

a fluid source connected to the therapy zone via the inflow line;

a pump connected to the factor source and the inflow line;

a controller connected to the pump and programmed for controlling the operation of the pump in response to simulated therapy zone conditions;

said manifold comprising a fluid-permeable foam material and manifold tubing fluidically connected to said foam material;

said controller applying a pulse wave in said simulated therapy zone with a simulated in vivo pressure differential chosen from among the group comprising circulatory, lymphatic or respiratory;

a pressure force sensor embedded in said medium material and adapted for sensing a pressure force effect including fluid pressure source amplitude and frequency therein;

an output connected to said pressure force sensor and adapted for providing output corresponding to said sensed pressure force effect and including amplitude and frequency of pressure waves in said medium material;

wherein said medium material comprises a synthetic gel; and

wherein said synthetic gel comprises a synthetic material with soft-tissue characteristics.

2. The system according to claim 1, which includes:

laser optical sensors mounted on said container and configured for projecting a laser energy beam into said medium material and providing an output representing frequency and amplitude of said pressure waves in said medium material;

said laser optical sensors having orientations relative to said medium material, said sensor orientations being user-adjustable; and

said controller connected to said laser optical sensor, said controller programmed for;

generating liquid pressure pulses in said medium material with said pump discharge;

controlling the amplitude and frequency of said liquid pressure pulses;

providing an output modeling simulated in vivo blood pressure including frequency and amplitude parameters in said medium material based on the input received from said laser optical sensor; and

controlling said liquid pressure pulse frequency and amplitude based on preprogrammed parameters.