Methods and systems for monitoring intrabody tissues

• US 9,572,511 B2
• Filed: 03/04/2010
• Issued: 02/21/2017
• Est. Priority Date: 09/05/2007
• Status: Active Grant

• Current Assignee: Sensible Medical Innovations Ltd.
• Original Assignee: Sensible Medical Innovations Ltd.
• Inventors: Kochba, Ilan, Rappaport, Dan, Saroka, Amir, Bergida, Shlomi, Mizrahi, Nadav, Ronen, Amir
• Primary Examiner(s): Fernandez, Katherine
• Assistant Examiner(s): KELLOGG, MICHAEL S
• Application Number:
  US13/254,852
• Publication Number:
  US 20110319746A1
• Time in Patent Office: 2,546 Days
• Field of Search: 600/407
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4504 Bones A61B5/4547 takes precedence
• CPC Class Codes: A61B 5/4842 Monitoring progression or stage of a disease
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence

Abstract

A method for monitoring an intrabody region of a patient. The method comprises intercepting electromagnetic (EM) radiation from the intrabody region in a plurality of EM radiation sessions during a period of at least 6 hours, calculating a dielectric related change of the intrabody region by analyzing respective the intercepted EM radiation, detecting a physiological pattern according to said dielectric related change. and outputting a notification indicating the physiological pattern.

Claims

1. A method for non-invasive monitoring of an intrabody region of a patient, comprising:

attaching a non-invasive probe of a monitoring device to a body of a patient;

intercepting, by said monitoring device, electromagnetic (EM) radiation from a cancerous tissue in the intrabody region of a patient undergoing oncological therapy in a plurality of EM radiation sessions during a period of said oncological therapy;

calculating by a hardware processor an expected signal based on anatomical reconstruction of a region of interest comprising said cancerous tissue and based on an expected change of a dielectric related property of the cancerous tissue in the intrabody region, said expected change is triggered by a member selected from a group consisting of a change in a tumor density in the cancerous tissue, cancerous tumor growth, and tumor remission;

detecting a physiological pattern of said cancerous tissue during said period of said oncological therapy according to an analysis of a plurality of resultant signals of the EM radiation intercepted in each of two or more different EM radiation sessions of said plurality of EM radiation sessions and said expected signal; and

outputting a notification indicating said physiological pattern;

wherein said EM radiation propagates from said cancerous tissue through at least a skin layer of said patient.

2. The method of claim 1, wherein the patient is an ambulatory patient and said intercepting being performed during a period of at least 12 hours.

3. The method of claim 1, wherein said dielectric related property reflects a change in a plurality of properties of said intrabody region.

4. The method of claim 3, wherein said plurality of properties comprises a property selected from a group consisting of:

a size, a shape, and a concentration of fluids.

5. The method of claim 1, wherein said calculating comprising registering EM radiations intercepted during a first of said plurality of EM radiation sessions with a second of said plurality of EM radiation sessions.

6. The method of claim 1, wherein said oncological therapy of said cancerous tissue is a member selected from a group consisting of:

a chemotherapy cycle, a biologic treatment and a radiation treatment.

7. The method of claim 1, further comprising automatically dispensing a medical substance into said patient according to said physiological pattern.

8. The method of claim 1, wherein said notification comprises a recommendation to perform a medical procedure according to said physiological pattern.

9. The method of claim 8, wherein said medical procedure comprising a member of a group consisting of:

a dosage of a medical agent, a dispensing of a medical substance, a radiation protocol, a rehabilitation process, and a diagnosis procedure.

10. The method of claim 1, wherein said detecting is further performed according to at least one biological parameter of said patient.

11. The method of claim 10, wherein said at least one biological parameter comprises a member of a group consisting of:

an electrocardiogram (ECG) signal, a temperature, a body orientation, a body acceleration, a hemodynamic parameter, CO2 saturation, O2 saturation, a pulse wave and a blood pressure.

12. The method of claim 1, wherein said detecting is further performed according to at least one diagnostic result related to said intrabody region.

13. The method of claim 1, further comprising using an imaging modality for performing, said anatomical reconstruction.

14. The method of claim 1, wherein said detecting a physiological pattern is based on a location parameter extracted from a modality imaging said intrabody region.

15. The method of claim 1 wherein said detecting comprises combining two narrowband signals from said EM radiation.

16. The method of claim 1, wherein said non-invasive monitoring device is wearable.

17. The method of claim 1, wherein said intercepted EM radiation passes through the intrabody region.

18. The method of claim 1, wherein said physiological pattern is indicative of at least one of an increase and a decrease in the size of a tumor in said cancerous tissue.

19. The method of claim 1, wherein said oncological therapy is a chemotherapy cycle;

the method further comprising matching said physiological pattern with an expected reaction estimated for said chemotherapy cycle.

20. The method of claim 1, further comprising adjusting a titration process given to said patient according to said physiological pattern.

21. The method of claim 1, further comprising identifying an oncogenic pathway according to said physiological pattern and determining a concentration for a medicament according to said physiological pattern and contingent on said oncogenic pathway.

22. The method of claim 1, wherein said physiological pattern is indicative of a member of a group consisting of:

a necrosis percentage of said cancerous tissue, a change in the vascular density of a tumor in said cancerous tissue, a change in a bleeding rate said tumor caused, a change in morphology of said tumor which is affected by the amount of blood therein, and a change in the blood supply in the vicinity of said tumor.

23. The method of claim 1, wherein said notification is an alert generated when said physiological pattern is indicative of a deviation from an expected outcome of said oncological therapy.

24. The method of claim 1, wherein said dielectric related change reflects a change in a plurality of properties of said cancerous tissue.

25. The method of claim 24, wherein said plurality of properties comprises a member of a group consisting of a density, a size, a shape, and a concentration of fluids.

26. The method of claim 1, wherein said intercepting comprises registering EM radiations intercepted during a first of a plurality of EM radiation sessions held during a period with a second of said plurality of EM radiation sessions.

27. The method of claim 1, wherein said attaching comprises providing a user with indications for positioning said non-invasive probe on said body such that a region of interest that includes the intrabody region is monitored in a similar manner in a plurality of monitoring events.

28. The method of claim 1, wherein said attaching comprises registering said non-invasive probe device with respect to an imaging modality.

29. The method of claim 1, wherein said expected signal is a differential signal.

30. A non-invasive monitoring device for detecting a physiological pattern of a cancerous tissue of an intrabody region, comprising:

at least one non-invasive probe configured for intercepting electromagnetic (EM) radiation passing through the skin of a patient from a cancerous tissue in an intrabody region of said patient undergoing oncological therapy;

a memory storing code; and

a hardware processor coupled to said at least one non-invasive probe first interface and said memory for executing the stored code, the code comprising;

code instructions for calculating an expected signal based on anatomical reconstruction of a region of interest comprising said cancerous tissue and based on an expected change of a dielectric related property of the cancerous tissue in the intrabody region, said expected change is triggered by a member selected from a group consisting of a change a tumor density in the cancerous tissue, cancerous tumor growth, and tumor remission, and

code instructions for detecting a physiological pattern of said cancerous tissue during a period of said oncological therapy according to an analysis of a plurality of resultant signals of the EM radiation intercepted in each of two or more different EM radiation sessions of said plurality of EM radiation sessions and said expected signal; and

an output unit configured for outputting a message indicating said physiological pattern;

wherein said probe and said hardware processor are configured for respectively performing said intercepting and said calculating in a plurality of EM radiation sessions during the period of said oncological therapy.

31. The non-invasive monitoring device of claim 30, wherein said output unit is connected to a medical device providing a treatment to said patient, said medical device being configured for providing said treatment according to said message.

32. The non-invasive monitoring device of claim 30 wherein said at least one probe is configured for intercepting at least some of said electromagnetic (EM) radiation from a reference intrabody region of said patient;

and wherein said hardware processor is configured for calculating a dielectric related change in said intrabody region and a reference dielectric related change in said reference intrabody region according to said intercepted EM radiation and detecting said physiological pattern according to said dielectric related change.