Spray or drip tips having multiple outlet channels

• US 9,572,555 B1
• Filed: 09/24/2015
• Issued: 02/21/2017
• Est. Priority Date: 09/24/2015
• Status: Active Grant

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Lai, Gwan-Ywan, Jeffcoat, Keith L.
• Primary Examiner(s): Kim, Christopher
• Assistant Examiner(s): Le, Viet
• Application Number:
  US14/863,489
• Time in Patent Office: 516 Days
• Field of Search: 239/541, 239436-449, 239/570, 239/571, 239/574, 239/579, 239/310, 239/304, 239/321, 239/329, 239/418, 239/416.5, 239/427, 239/463, 239/466, 239/461, 239/399, 239/303, 239/398, 222/137, 222/145.1, 222/145.5, 222/145.6, 604/84, 604/82, 604/83, 604/191, 604/187
• US Class Current: 1/1
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61B 2017/00522 Sprayers
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: B05B 7/0408 with arrangements for mixing two or more liquids

Abstract

The present invention is directed to devices for mixing and expressing a multi-component sealant or hemostat or adhesive comprising at least two containers configured to contain and express two reactive components into separate lumens of a cannula. An elongated expression tip having a main channel that is open at a proximal end with the cannula slidably fits into the main channel. The tip contains a plurality of separate mixing chambers open at the distal end of the tip, wherein each of the mixing chambers is in fluid communication with the main channel via an individual connecting channel. Openings for each of the connecting channels are provided at different distances from the distal end. The tip is configured to slide on the cannula and advance distally when the main channel is pressurized due to an obstruction in at least one of the mixing chambers.

Claims

1. A device for delivering an at least partially mixed multi-component sealant or hemostat or adhesive formulation comprising:

a) at least two containers of at least two separate, reactive components in fluid communication with at least two separate lumens of a multi-lumen cannula having outlets distal to the containers;

b) an expression tip having a main channel that is open at a proximal end to the cannula and fitted over and beyond the cannula outlets;

wherein the tip comprises a plurality of separate mixing chambers having outlets at the distal end of the tip and in fluid communication with the main channel via corresponding individual connecting channels, each individual connecting channel set at one of a plurality of distances relative to the distal end of the tip;

wherein the tip moves distally when the main channel is pressurized due to an obstruction in at least one mixing chamber.

2. The device of claim 1, wherein said mixing chambers each terminate at the distal end of the tip with a spray port or an atomizing spray nozzle.

3. The device of claim 1, wherein said mixing chambers each terminate at the distal end of the tip with a drip port or a drip nozzle.

4. The device of claim 1, wherein said mixing chambers contain at least one of static mixing element and wherein at least some of said mixing chambers terminate at the distal end of the tip with a drip port or a drip nozzle wherein at least some of said mixing chambers terminate at the distal end of the tip with a spray port or an atomizing spray nozzle.

5. The device of claim 1, wherein a spring is attached to the tip that resists distal tip movement and wherein the tip is configured to be manually advanced distally or turned to switch to another mixing chamber.

6. The device of claim 1, wherein the main channel is pressurized due to a clog of at least partially reacted sealant.

7. The device of claim 1, wherein only upon the tip advancing distally, the connecting channel which is farther from the distal end of the tip begins to convey the multi-component sealant into its corresponding mixing chamber.

8. The device of claim 1, wherein prior to dispensing any reactive components, all but one of the connecting channels is blocked by the cannula and are not in fluid communication with the main channel.

9. The device of claim 1, wherein the multi-component sealant or hemostat or adhesive upon reaction comprises a fibrin glue, wherein the first component of the multi-component sealant comprises fibrinogen or fibrinogen analog, and wherein the second component of the multi-component sealant comprises an agent that converts fibrinogen to fibrin, preferably thrombin of thrombin precursor.

10. The device of claim 1, wherein the multi-component sealant or hemostat or adhesive upon reaction comprises a synthetic polymeric material, wherein the first component of the multi-component sealant comprises a cross-linkable compound, and the second component of the multi-component sealant comprises a cross-linking agent.

11. A method of mixing and expressing a multi-component sealant or hemostat or adhesive comprising

a) connecting at least two containers configured to contain and express two components to separate lumens of a multi-lumen cannula;

b) connecting an elongated expression tip having a main channel open at a proximal end to the cannula, wherein the cannula is configured to slidably fit into the main channel;

wherein the tip contains a plurality of separate mixing chambers open at the distal end of the tip, each of the mixing chambers being in fluid communication with the main channel via an individual connecting channel at separate and distinct distances from the tip on the cannula;

c) advancing the two components through separate lumens of the multi-lumen cannula without mixing to the tip;

d) mixing the two components within a first mixing chamber; and

e) expressing the components through a first opening at the distal end of the tip;

f) upon clogging of the first mixing chamber, continuing to advance the two components through separate lumens of the multi-lumen cannula thus pressurizing the main channel;

g) allowing the tip to slide on the cannula and advance distally to place a second mixing chamber in fluid communication with the main channel;

h) mixing the two components within the second mixing chamber; and

i) expressing the components through a second opening at the distal end of the tip.

12. The method of claim 11, wherein said mixing chambers each terminate at the distal end of the tip with a spray port or an atomizing spray nozzle.

13. The method of claim 11, wherein said mixing chambers each terminate at the distal end of the tip with a drip port or a drip nozzle.

14. The method of claim 11, wherein said mixing chambers contain at least one of static mixing element and wherein at least some of said mixing chambers terminate at the distal end of the tip with a drip port or a drip nozzle wherein at least some of said mixing chambers terminate at the distal end of the tip with a spray port or an atomizing spray nozzle.

15. The method of claim 11, wherein a spring is attached to the tip that resists distal tip movement and wherein the tip is configured to be manually advanced distally or turned to switch to another mixing chamber.

16. The method of claim 11, wherein the main channel is pressurized when the mixing chamber is clogged by an at least partially reacted multi-component sealant.

17. The method of claim 11, wherein upon the tip advancing distally, a second connecting channel that is farther from the distal end of the tip than the first connecting channel is in fluid communication with the multi-component sealant.

18. The method of claim 11, wherein prior to dispensing any components, all but one connecting channels are blocked by the cannula and are not in fluid communication with the main channel.

19. The method of claim 11, wherein the multi-component sealant or hemostat or adhesive upon reaction comprises a fibrin glue, wherein the first component of the multi-component sealant comprises fibrinogen or fibrinogen analog, and wherein the second component of the multi-component sealant comprises an agent that converts fibrinogen to fibrin, preferably thrombin of thrombin precursor.

20. The method of claim 11, wherein the multi-component sealant or hemostat or adhesive upon reaction comprises a synthetic polymeric material, wherein the first component of the multi-component sealant comprises a cross-linkable compound, and the second component of the multi-component sealant comprises a cross-linking agent.