Phase-change and shape-change materials

• US 9,572,695 B2
• Filed: 08/22/2010
• Issued: 02/21/2017
• Est. Priority Date: 08/24/2009
• Status: Active Grant

• Current Assignee: New Phase, Ltd.
• Original Assignee: New Phase, Ltd.
• Inventors: Hof, Rafael, Perevalov, Valery
• Primary Examiner(s): Stoklosa, Joseph
• Assistant Examiner(s): Pobre, Nicole L
• Application Number:
  US13/392,037
• Publication Number:
  US 20120221081A1
• Time in Patent Office: 2,375 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2007/0292 using latent heat produced or absorbed during phase change of materials, e.g. of super-cooled solutions
• CPC Class Codes: A61F 2210/0014 using shape memory or superelastic materials, e.g. nitinol
• CPC Class Codes: A61F 2210/0061 swellable
• CPC Class Codes: A61F 2210/0066 shrinkable
• CPC Class Codes: A61F 2210/008 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 1/086 Magnetic resonance imaging [MRI] compatible leads
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: A61N 2007/0039 using microbubbles

Abstract

Apparatus and methods are described for killing cancer cells (44) of a subject, the subject having cancer cells and healthy cells. The apparatus includes a plurality of first molecules (40) configured to be coupled to the cancer cells to a greater extent than to the healthy cells, in response to being administered to the subject. A plurality of clusters (42) of phase-change molecules are provided, each of the clusters coupled to a respective one of the first molecules. An energy transmission unit (50) kills cancer cells coupled to the first molecules by heating the cancer cells, by transmitting energy toward the clusters that selectively heats the clusters. Other embodiments are also described.

Claims

1. Apparatus for killing cancer cells of a body of a subject, the subject'"'"'s body having cancer cells and healthy cells, the apparatus comprising:

a plurality of first molecules configured to be coupled to the cancer cells to a greater extent than to the healthy cells, in response to being administered to the subject;

a plurality of molecules of a phase-change material, each of the first molecules being coupled to at least some of the phase-change material molecules, the phase-change material molecules being configured, upon being heated to a characteristic phase-change temperature of the phase-change material, to undergo a phase change selected from the group consisting of;

wax to liquid, solid to liquid, solid to gel, and gel to liquid; and

an energy transmission unit, configured to;

kill cancer cells coupled to the first molecules by heating the cancer cells to the phase-change temperature of the phase-change material, by transmitting energy toward at least a portion of the subject'"'"'s body, and

avoid heating the phase-change material molecules above the phase-change temperature of the phase-change material, by discontinuing the transmission of energy after a given time period,

the phase-change material molecules being configured to prevent a region of the subject'"'"'s body in which the phase-change material molecules are disposed from being heated above the phase-change temperature, by the phase-change material molecules absorbing latent heat of fusion.

2. The apparatus according to claim 1, wherein the energy transmission unit is configured to rupture membranes of the cancer cells by heating the cancer cells.

3. The apparatus according to claim 1, wherein the energy transmission unit is configured to transmit energy at a resonance frequency of the phase-change material molecules.

4. The apparatus according to claim 1, wherein the phase-change material molecules comprise paraffin molecules.

5. The apparatus according to claim 1, wherein the phase-change material molecules comprise molecules of an organic phase-change material.

6. The apparatus according to claim 1, wherein the first molecules comprise glucose molecules.

7. The apparatus according to claim 1, wherein the phase-change temperature of the phase-change material is between 60 and 80 C.

8. The apparatus according to claim 1, wherein the phase-change temperature of the phase-change material is between 45 and 60 C.

9. A method, for killing cancer cells of a body of a subject, the subject'"'"'s body having the cancer cells and healthy cells, the method comprising:

administering to the subject a plurality of first molecules, each of the first molecules having a plurality of molecules of a phase-change material coupled thereto,

the first molecules being configured to be coupled to the cancer cells to a greater extent than to the healthy cells, and

the phase-change material molecules being configured, upon being heated to a characteristic phase-change temperature of the phase-change material, to undergo a phase change selected from the group consisting of;

wax to liquid, solid to liquid, solid to gel, and gel to liquid;

killing the cancer cells by heating the cancer cells to the phase-change temperature of the phase-change material, by transmitting energy toward at least a portion of the subject'"'"'s body; and

avoiding heating the phase-change material molecules above the phase-change temperature of the phase-change material, by discontinuing the transmission of energy after a given time period,

the phase-change material molecules preventing a region of the subject'"'"'s body in which the phase-change material molecules are disposed from being heated above the phase-change temperature, by the phase-change material molecules absorbing latent heat of fusion.

10. The method according to claim 9, wherein heating the cancer cells comprises rupturing membranes of the cancer cells.

11. The method according to claim 9, wherein transmitting energy toward the portion of the subject'"'"'s body comprises irradiating multiple sites to which the cancer cells may have metastasized.

12. The method according to claim 9, wherein transmitting energy toward the portion of the subject'"'"'s body comprises transmitting energy at a resonance frequency of the phase-change material molecules.

13. The method according to claim 9, wherein transmitting energy toward the portion of the subject'"'"'s body comprises heating the portion of the subject'"'"'s body to a temperature of between 45 C and 60 C.

14. The method according to claim 9, wherein transmitting energy toward the portion of the subject'"'"'s body comprises heating the portion of the subject'"'"'s body to a temperature of between 60 C and 80 C.

15. The method according to claim 9, further comprising imaging the subject while transmitting energy toward the portion of the subject'"'"'s body.

16. The method according to claim 15, wherein imaging the subject comprises imaging the cancer cells using a heat-sensitive imaging protocol.