Osmotically actuated fluidic valve

• US 9,572,712 B2
• Filed: 11/26/2013
• Issued: 02/21/2017
• Est. Priority Date: 12/17/2012
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Gunn, Nicholas Max
• Primary Examiner(s): Deak, Leslie
• Application Number:
  US14/090,192
• Publication Number:
  US 20140172090A1
• Time in Patent Office: 1,183 Days
• US Class Current: 1/1
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0543 Retinal electrodes

Abstract

An implantable fluidic valve actuated by osmotic pressure gradient and methods of operating it are provided. The valve includes: an input fluid channel; an output fluid channel in fluid communication with the input fluid channel at an aperture; and a semi-permeable membrane forming a portion of a sealed chamber. The semi-permeable membrane may have an outer surface forming a wall of the input fluid channel, and an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and a first electrode and a second electrode disposed within the sealed chamber configured to receive a voltage. A pump including the above elements and a check valve is provided. An ocular implant including an inlet tube sized to receive aqueous humor and an intra-ocular pressure control system having a fluidic valve as above is also provided.

Claims

1. An implantable fluidic valve actuated by osmotic pressure gradient including:

an input fluid channel;

an output fluid channel in fluid communication with the input fluid channel at an aperture;

a semi-permeable membrane forming a portion of a sealed chamber, the semi-permeable membrane having an outer surface forming a wall of the input fluid channel, and having an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and

a first electrode and a second electrode disposed within the sealed chamber configured to receive a voltage.

2. The implantable fluidic valve of claim 1 wherein the sealed chamber comprises an electrolyte solution.

3. The implantable fluidic valve of claim 2 wherein the electrolyte solution includes a compound selected from the group consisting of copper sulfate, zinc sulfate and a silver salt.

4. The implantable fluidic valve of claim 2 wherein the electrodes comprise a conducting material having an electro-plating voltage higher than an electro-plating voltage of a plated layer formed with ions from the electrolyte solution.

5. The implantable fluidic valve of claim 1 wherein the electrodes are made of a material selected from the group consisting of platinum and gold.

6. The implantable fluidic valve of claim 1 wherein the semi-permeable membrane comprises a non-porous material.

7. The implantable fluidic valve of claim 1 wherein the solvent is water.

8. The implantable fluidic valve of claim 1 further comprising an inlet tube in communication with the input fluid channel, the inlet tube being sized for implantation in an eye of a patient.

9. The implantable fluidic valve of claim 1 further comprising a one way check valve associated with one of the input and output fluid channels.

10. The implantable fluidic valve of claim 1, wherein the membrane is configured to displace from a first position relative to the aperture to a second position relative to the aperture to increase or decrease a fluid flow rate through the aperture.

11. The implantable fluidic valve of claim 1 further comprising a deformable and flexible diaphragm forming a part of the sealed chamber.

12. The implantable fluidic valve of claim 1, further comprising a processor and a sensor, the processor controlling voltage to the electrodes based on feedback from the sensor.

13. An ocular implant for treating an ocular condition, comprising:

an inlet tube sized to receive aqueous humor; and

an intra-ocular pressure (TOP) control system to regulate drainage of aqueous humor from the inlet tube;

the TOP control system comprising a fluidic valve comprising;

an input fluid channel coupled to the inlet tube;

an output fluid channel in communication with the input fluid channel at an aperture; and

a semi-permeable membrane configured to selectively displace relative to the aperture, the membrane having an outer side adjacent the input fluid channel and an inner side forming a part of a chamber, the chamber comprising;

a first electrode and a second electrode configured to affect free ions in the chamber.

14. The ocular implant of claim 13 wherein the chamber comprises an electrolyte solution including copper sulfate.

15. The ocular implant of claim 13 wherein the first electrode and the second electrode comprise a conducting material having an electro-plating voltage higher than an electro-plating voltage of a plated layer formed with ions from an electrolyte solution disposed in the chamber.

16. An ocular implant for treating an ocular condition, comprising:

an input fluid channel;

an output fluid channel in fluid communication with the input fluid channel at an aperture;

a semi-permeable membrane forming a portion of a sealed chamber, the semi-permeable membrane having an outer surface forming a wall of the input fluid channel, and having an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and

a first electrode and a second electrode disposed within the sealed chamber to change a volume of the chamber.

17. The ocular implant of claim 16 further comprising a non-permeable membrane forming another portion of the sealed chamber, the non-permeable membrane having an inner surface forming another wall of the sealed chamber.

18. The ocular implant of claim 17 wherein the semi-permeable membrane is non-deformable and the non-permeable membrane is deformable.

19. The ocular implant of claim 17 further comprising:

a first check valve positioned between the input fluid channel and the non-permeable membrane; and

a second check valve positioned between the output fluid channel and the non-permeable membrane.

20. The ocular implant of claim 19 wherein the first check valve and second check valve are configured such that the first check valve closes and the second check valve opens when the non-permeable membrane deforms into a pump chamber defined between the first check valve and second check valve.