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Compositions with a rheological modifier to reduce dissolution variability

  • US 9,572,885 B2
  • Filed: 03/14/2014
  • Issued: 02/21/2017
  • Est. Priority Date: 03/15/2013
  • Status: Expired due to Fees
First Claim
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1. A composition comprising:

  • a pharmacologically active agent;

    a high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37°

    C. that does not crystallize neat at 25°

    C. and 1 atmosphere;

    a solvent;

    a network former;

    water; and

    a mineral particle, wherein the mineral particle is present in the composition in an amount from 2.4% by weight to about 5.4% by weight relative to the total weight of the composition,wherein the composition does not comprise more than 2.0% water by weight, based on total weight of the composition.

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