Substance delivery devices, systems and methods

• US 9,572,928 B2
• Filed: 03/11/2014
• Issued: 02/21/2017
• Est. Priority Date: 03/13/2013
• Status: Active Grant

• Current Assignee: Clearpoint Neuro, Inc.
• Original Assignee: MRI Interventions, Inc. (Clearpoint Neuro, Inc.)
• Inventors: Shifflette, J. Michael, Piferi, Peter
• Primary Examiner(s): SCHMIDT, EMILY LOUISE
• Application Number:
  US14/204,378
• Publication Number:
  US 20140276582A1
• Time in Patent Office: 1,078 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 25/02 Holding devices, e.g. on the body
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure

Abstract

A substance delivery device includes an elongated tubular body having opposing proximal and distal ends, and a diaphragm that is in slideable sealing engagement with an inside wall of the tubular body. The diaphragm is movable in opposite first and second directions within the tubular body. A substance is contained within the tubular body between the diaphragm and the tubular body distal end, and a slave fluid is contained within the tubular body between the diaphragm and the tubular body proximal end. When pressure is exerted on the slave fluid, the slave fluid causes the diaphragm to move and eject the substance through the tubular body distal end.

Claims

1. A system for delivering a substance to a patient, the system comprising:

a trajectory guide configured to be secured to a body of the patient;

a cannula supported by the trajectory guide, the cannula comprising a cannula body defining at least one longitudinally extending lumen, an inlet port, and at least one exit port, wherein the trajectory guide provides X-Y adjustment and pitch and roll adjustment for the cannula;

a substance delivery device, comprising;

an elongated tubular body comprising opposing proximal and distal ends, each of the proximal and distal ends comprising a respective connector;

a diaphragm that is in slideable sealing engagement with an inside wall of the tubular body, wherein the diaphragm is movable in opposite first and second directions within the tubular body; and

a slave fluid contained within the tubular body between the diaphragm and the tubular body proximal end; and

a syringe in fluid communication with the tubular body proximal end via first flexible tubing having a connector that is matingly and removably secured to the tubular body proximal end connector, wherein the syringe and the first flexible tubing contain the slave fluid, wherein activation of the syringe to cause the slave fluid to move the diaphragm in the second direction causes a substance to be loaded within the tubular body between the diaphragm and the tubular body distal end;

wherein the at least one longitudinally extending lumen of the cannula is fluidly connected to the tubular body distal end via second flexible tubing, and wherein the cannula is adapted to transfer the substance from the tubular body to a selected location in the patient via the at least one exit port upon activation of the syringe to cause the slave fluid to move the diaphragm in the first direction.

2. The system of claim 1, wherein the second tubing comprises a connector that is matingly and removably connected to the tubular body distal end connector.

3. The system of claim 1, wherein the cannula is MRI-compatible.

4. The system of claim 1, wherein the substance delivery device is formed of MRI-compatible material.

5. The system of claim 1, further comprising a pump adapted to move a plunger in the syringe and cause the slave fluid to move the diaphragm in the first and second directions.

6. The system of claim 1, wherein a volume of the substance is less than twenty microliters (20 μ

L).

7. The system of claim 1, wherein a volume of the substance is between about twenty microliters (20 μ

L) and about thirty milliliters (30 cc).

8. The system of claim 1, wherein the substance is a liquid medicament.

9. The system of claim 8, wherein the liquid medicament is a brain therapy medicament.

10. The system of claim 1, wherein an exterior surface of the cannula has at least first and second co-axially disposed segments having different outer diameters.

11. The system of claim 10, wherein the exterior surface includes a tapered transition between the first and second segments.

12. The system of claim 1, wherein the first flexible tubing has a first length, and wherein the second flexible tubing has a second length that is substantially less than the first length.

13. The system of claim 12, wherein the first length is at least about six feet (6 ft).