Medicament delivery device and method of controlling the device

• US 9,572,932 B2
• Filed: 05/24/2012
• Issued: 02/21/2017
• Est. Priority Date: 05/25/2011
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Eggert, Ilona, Langley, Christopher Nigel, Day, Shane Alistair
• Primary Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US14/119,157
• Publication Number:
  US 20140081234A1
• Time in Patent Office: 1,734 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/1787 Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2474 with movable piercing means, e.g. ampoule remains fixed or steady
• CPC Class Codes: A61M 2005/2496 via pivot
• CPC Class Codes: A61M 2005/3118 via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: A61M 5/345 Adaptors positioned between needle hub and syringe nozzle
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Described is a needle assembly reuse prevention mechanism comprising a barrier movable between a retracted position and an extended position, a spring coupled to the barrier, a pin formed on the barrier, and a slot receiving the pin. When in the extended position, the barrier substantially covers an opening of a needle assembly storage compartment. The spring forces the barrier in a first direction. The slot has at least one abutment face for abutting the pin and preventing movement of the barrier in the first direction.

Claims

1. A medicament delivery device for the administration of one or more drug agents, the device having (i) a priming mode for priming the device and (ii) a drug delivery mode for administering delivery of a dose of the one or more drug agents, wherein the device has a plurality of states including a predetermined state, wherein the device comprises a controller operative for:

determining which of the plurality of states the device is in;

responsive to the controller determining that the device is in the predetermined state, setting the device in the priming mode and disabling the drug delivery mode during said predetermined state; and

responsive to the controller determining that the device is in a state different than the predetermined state, setting the device in the drug delivery mode while maintaining enablement of the priming mode through a user interface,

wherein the user interface is configured to provide a first selectable option for priming the device and a second selectable option for delivering a dose,

wherein, to set the device in the priming mode and disable the drug delivery mode, the controller is operative to cause the user interface to provide the first selectable option and not the second selectable option to thereby set the device in a mandatory priming mode, and

wherein, to set the device in the drug delivery mode while maintaining enablement of the priming mode, the controller is operative to cause the user interface to provide both the first selectable option and the second selectable option.

2. A medicament delivery device according to claim 1, wherein the controller determines that the device is in said predetermined state when the controller determines that a dispense interface is placed from a detached to an attached relationship with the device.

3. A medicament delivery device according to claim 1, wherein the controller that the device is in said predetermined state when the controller determines that a dispense interface is attached to the device and no dose of medicament has been dispensed from the device since the attachment of the dispense interface to the device.

4. A medicament delivery device according to claim 1, wherein the medicament delivery device comprises a first retainer and a second retainer each for holding a medicament cartridge containing a drug agent.

5. A medicament delivery device according to claim 4, comprising a detachable dispense interface having a bifurcated conduit for providing fluid communication from the first and second retainers to a unitary outlet.

6. A medicament delivery device according to claim 5, wherein the unitary outlet comprises an attachment for a needle.

7. A medicament delivery device according to claim 4, wherein, to prime the device, the controller is operative to dispense fluid from the medicament cartridges of the first and the second retainers respectively when the device is in said predetermined state.

8. A medicament delivery device according to claim 1, wherein the device comprises an output device and the controller is operative to prompt the user, via the output device, to prime the device when said controller determines the device is in said predetermined state.

9. A medicament delivery device according to claim 4, wherein when the device is set in the drug delivery mode while maintaining enablement of the priming mode, the controller is operative for priming the device from a designated one of the medicament cartridges of the first and the second retainers provided the time that has elapsed since a previous dose or since a previous priming of the device is less than a predetermined value.

10. A medicament delivery device according to claim 4, wherein when the device is set in the drug delivery mode while maintaining enablement of the priming mode, the controller is operative for priming the device from both of the medicament cartridges of the first and the second retainers if the time that has elapsed since a previous dose or since a previous priming of the device is greater than a predetermined value.

11. A medicament delivery device according to claim 4, wherein the controller is operative to eject medicament from the medicament cartridges the first and second retainers at different rates with respect to one another during enablement of the priming mode.

12. A medicament delivery device according to claim 1, wherein the priming mode ejects a quantity of medicament from the device that is preset by the controller.

13. A medicament delivery device according to claim 12, wherein in the priming mode, the controller is operable to eject the quantity of medicament in a number of discrete units, the number of the discrete units being selected through a user interface.

14. A medicament delivery device according to claim 12, wherein the preset quantity of medicament is dependent on the identified predetermined state.

15. A medicament delivery device according to claim 1, wherein a dose setting device is enabled during the drug delivery mode.

16. A medicament delivery device according to claim 1, wherein the device is hand-held and/or is a pen-type injection device.

17. A medicament delivery device for the administration of a medicament, the device having (i) a priming mode for discharging air or a residual medicament from the device and (ii) a drug delivery mode for administering delivery of a dose of the medicament, wherein the device has a plurality of states including one or more first states and one or more second states, wherein the device comprises:

a user interface having a priming button for activating the priming mode and a dose-delivery button for activating the drug delivery mode; and

a controller operative for;

determining whether the device is in at least one of the one or more first states or at least one of the one or more second states,

responsive to determining that the device is in at least one of the one or more first states, enabling the priming mode via the priming button and disabling the drug delivery mode via the drug-delivery button during the at least one of the one or more first states, wherein enabling the priming mode and disabling the drug-delivery modes sets the device in a mandatory priming mode, and

responsive to determining that the device is in at least one of the one or more second states, enabling the priming mode via the priming button and enabling the drug delivery mode via the drug-delivery button during the at least one of the one or more second states.