Automatic injection device

• US 9,572,938 B2
• Filed: 10/06/2011
• Issued: 02/21/2017
• Est. Priority Date: 06/30/2006
• Status: Active Grant

• Current Assignee: AbbVie Biotechnology Ltd. (Puerto Rico) (Abbvie Incorporated)
• Original Assignee: AbbVie Biotechnology Ltd. (Puerto Rico) (Abbvie Incorporated)
• Inventors: Julian, Joseph F., Rolfe, Steven, Bicknell, Stephen, Marshall, Jeremy
• Primary Examiner(s): Utama, Robert J
• Assistant Examiner(s): FLETCHER, JERRY-DARYL
• Application Number:
  US13/267,467
• Publication Number:
  US 20120107783A1
• Time in Patent Office: 1,965 Days
• Field of Search: 434/262
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/31508 provided on the piston-rod
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2209/02 Equipment for testing the apparatus
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: G09B 23/285 for injections, endoscopy, bronchoscopy, sigmoidscopy, insertion of contraceptive devices or enemas
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

An automatic injection device for providing a subcutaneous injection is disclosed. The device includes a syringe movably disposed in a housing and including a barrel portion, a needle and a bung for sealing the barrel portion. The device includes a plunger for moving the syringe towards a first open end of the housing such that the needle projects from the first end, and for subsequently applying pressure to the bung. The plunger includes a rod connected at a first end to the bung, a compressible expanded central portion, and a flange between a second end of the rod and the central portion. The device also includes a biasing mechanism for biasing the plunger towards the first open end of the housing, the biasing mechanism disposed about the second end of the rod between the flange and a second end of the housing.

Claims

1. A needleless automatic injection training device for training a recipient on administration of a substance, the training device comprising:

a cylindrical outer housing;

an activation button operatively coupled to the housing;

an audible mechanism to convey audible information to a user concerning operation of the training device;

a visual indicator, wherein the visual indicator conveys information to a user after a predetermined time period from depression of the activation button to simulate completion of an injection; and

wherein the training device is unsuitable for administering a substance.

2. The training device of claim 1, wherein the audible information is conveyed in response to an activation of the activation button.

3. The training device of claim 1, further comprising a visual indicator to convey visual information to the user.

4. The training device of claim 3, wherein the visual indicator conveys the visual information to the user in response to activation of the activation button.

5. The training device of claim 1, wherein the activation button initiates an operation of the training device.

6. The training device of claim 1, further comprising a syringe actuation component disposed within the housing, a transparent cylinder disposed within the housing, a rod movably disposed in the cylinder, and the visual indicator disposed on the rod, wherein depression of the activation button advances the syringe actuation component to expel air from the training device.

7. The training device of claim 1, wherein the training device lacks a member corresponding to a needle.

8. A kit for instructing a recipient on administration of a substance by injection, the kit comprising:

a training automatic injection device for demonstrating a procedure of using an automatic injection device, the training automatic injection device being unsuitable for administering a substance, the training automatic injection device including an activation button, a syringe actuation component and a visual indicator, wherein depression of the activation button advances the syringe actuation component, and wherein the visual indicator conveys information to a user after a predetermined time period from depression of the activation button to simulate completion of an injection; and

a non-transitory computer readable storage medium from which instructional information is conveyed to guide a recipient through the procedure with the training automatic injection device.

9. The kit of claim 8, wherein the training automatic injection device lacks a needle.

10. The kit of claim 8, wherein the training automatic injection device mimics the automatic injection device and comprises:

a housing having a window;

an activation button coupled to the housing; and

an indicator moveably disposed in the housing, the indicator having a first position in which the indicator is offset from the window and a second position in which the indicator aligns with the window,

wherein the indicator moves from the first position to the second position after activation of the activation button.

11. The kit of claim 8, wherein the instructional information comprises instructions audibly conveyed to the recipient.

12. The kit of claim 8, wherein the instructional information comprises instructions visually conveyed to the recipient.

13. The kit of claim 8, wherein the instructional information comprises instructions audibly and visually conveyed to the recipient.

14. The kit of claim 8, wherein the instructional information includes instructions for the user to position the training automatic injection device at an injection site, engage an activation mechanism to simulate injection, and maintain engagement of the activation mechanism until a visible indicator of completion is detected.

15. A system for training a recipient to administer a medication comprising:

an activation button associated with a housing of a needleless automatic injection training device that is unsuitable for administering a substance, the activation button being configured to simulate an actual activation mechanism of an automatic injection device;

an indicator associated with the housing, the indicator being configured to simulate an actual visual indicator of the automatic injection device; and

a non-transitory computer readable storage medium from which information associated with use of the activation button and the indicator is conveyed to the recipient,

wherein the indicator is not activated prior to actuation of the activation button,

wherein conveyance of the information guides the recipient on the use of the activation button, and

wherein actuation of the activation button causes the indicator to be activated.

16. The system of claim 15, further comprising a transparent cylinder disposed within the housing and a rod movably disposed within the transparent cylinder, wherein actuation of the activation button expels air from the training device.

17. The system of claim 15, wherein the housing includes a window, the indicator is disposed within the housing, and the indicator aligns with the window after actuation of the activation button.

18. The system of claim 15, wherein the information is conveyed audibly.

19. The system of claim 15, wherein the information is conveyed visually.

20. A kit for training a recipient on use of an automatic injection device comprises a needle and a medication, the kit comprising:

(a) a demonstration automatic injection device which lacks the needle and the medication, the demonstration automatic injection device including;

a housing having a window,

an activation button on a first end of the housing, and

an indicator movably disposed within the housing, wherein the indicator aligns with the window of the housing after a user activates the activation button; and

(b) instructions for using the automatic injection device.

21. The kit of claim 20, wherein the instructions for using the automatic injection device are provided in a printed document or in a non-transitory computer readable storage medium.

22. The kit of claim 21, wherein the non-transitory computer readable storage medium is a Video Home System (VHS) cassette or a Digital Video Disc (DVD).

23. The kit of claim 20, wherein the instructions further convey a method to the recipient for using the demonstration automatic injection device, the method comprising instructions to:

(a) position the automatic injection device at an injection site;

(b) engage the activator mechanism to begin injection of the medication;

(c) maintain engagement of the activator mechanism for a prescribed period of time to continue injection of the medication; and

(d) remove the automatic injection device from the injection site after passage of the prescribed period of time.

24. The kit of claim 23, wherein the prescribed period of time is 10 seconds.

25. The kit of claim 23, wherein the prescribed period of time is at least 10 seconds.

26. The kit of claim 20, wherein the instructions further convey that initial engagement of the activator mechanism is accompanied by an audible sound.

27. The kit of claim 20, wherein the instructions further convey that completion of injection of the medication is accompanied by a visible indicator of completion.

28. The kit of claim 20, wherein the instructions further convey that the injection site be sterilized prior to positioning the automatic injection device at the injection site.

29. The kit of claim 20, wherein the instructions further convey that the automatic injection device be examined for proper dosage and formulation of the medication prior to positioning the automatic injection device at the injection site.

30. The kit of claim 20, wherein the instructions further convey to the recipient, at least one message selected from the group consisting of:

(a) the automatic injection device is less painful for a patient to use than a pre-filled syringe;

(b) the automatic injection device is preferred for use by patients as compared to a pre-filled syringe;

(c) the automatic injection device is easier to use by a patient than a pre-filled syringe;

(d) the automatic injection device is more convenient for a patient to use than a pre-filled syringe;

(e) the automatic injection device reduces anxiety of patients with a fear of needles, as compared to a pre-filled syringe, since the needle is not visible in the device; and

(f) the automatic injection device is designed to be easy to use from initial use of the device.

31. The kit of claim 20, wherein the recipient is a physician that prescribes the medication.

32. The kit of claim 20, wherein the recipient is a patient that uses the medication.