Delivery device
First Claim
Patent Images
1. A device for delivery of material to a biological subject, the device comprising:
- a) a solid base; and
b) solid, non-porous, non-hollow projections extending from the base and at least partially coated with a non-liquid coating including the material, wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein;
i) the number of projections is at least 500;
ii) each projection has a length of between 200 μ
m and 1000 μ
m;
iii) each projection has a base width of between 5 μ
m and 50 μ
m;
iv) the projections are separated by a spacing of between 10 μ
m and 200 μ
m;
v) the tip is less than 500 nm in diameter; and
vi) the density of the projections is between 10 projections/mm2 to 100 projections/mm2.
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Abstract
A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
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Citations
21 Claims
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1. A device for delivery of material to a biological subject, the device comprising:
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a) a solid base; and b) solid, non-porous, non-hollow projections extending from the base and at least partially coated with a non-liquid coating including the material, wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m;iv) the projections are separated by a spacing of between 10 μ
m and 200 μ
m;v) the tip is less than 500 nm in diameter; and vi) the density of the projections is between 10 projections/mm2 to 100 projections/mm2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A device for delivery of a vaccine to a biological subject to produce an immune response within the biological subject comprising:
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a) a solid base; and b) a number of solid, non-porous, non-hollow projections extending from the base, wherein the projections are arranged in an array, and wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m;iv) the projections are separated by a spacing of between 10 μ
m and 200 μ
m;v) one or more of the projections are at least partially coated with a non-liquid vaccine; vi) the tip is less than 500 nm in diameter; and vii) the density of the projections is between 10 projections/mm2 to 100 projections/mm2.
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Specification