Compositions and methods for growth factor modulation
First Claim
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1. An antibody that binds to a protein complex, said protein complex comprising:
- a. glycoprotein-A repetitions predominant protein (GARP) comprising the amino acid sequence of SEQ ID NO;
159, andb. a growth factor prodomain complex (GPC) comprising human TGF-β
1 growth factor and human TGF-β
1 LAP;
wherein said antibody binds a GARP epitope of the protein complex, but does not bind free GARP.
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Abstract
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
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Citations
10 Claims
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1. An antibody that binds to a protein complex, said protein complex comprising:
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a. glycoprotein-A repetitions predominant protein (GARP) comprising the amino acid sequence of SEQ ID NO;
159, andb. a growth factor prodomain complex (GPC) comprising human TGF-β
1 growth factor and human TGF-β
1 LAP;wherein said antibody binds a GARP epitope of the protein complex, but does not bind free GARP. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification