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Compositions and methods for growth factor modulation

  • US 9,573,995 B2
  • Filed: 07/09/2015
  • Issued: 02/21/2017
  • Est. Priority Date: 05/06/2013
  • Status: Active Grant
First Claim
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1. An antibody that binds to a protein complex, said protein complex comprising:

  • a. glycoprotein-A repetitions predominant protein (GARP) comprising the amino acid sequence of SEQ ID NO;

    159, andb. a growth factor prodomain complex (GPC) comprising human TGF-β

    1 growth factor and human TGF-β

    1 LAP;

    wherein said antibody binds a GARP epitope of the protein complex, but does not bind free GARP.

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