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B7-H3L cell surface antigen and antibodies that bind thereto

  • US 9,574,007 B2
  • Filed: 06/03/2014
  • Issued: 02/21/2017
  • Est. Priority Date: 06/19/2002
  • Status: Expired due to Term
First Claim
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1. A method of treating cancer in a subject having a cancer comprising administering to the subject a composition comprising a therapeutically effective amount of an immunoglobulin polypeptide or an antigen-binding fragment thereof associated with a chemotherapeutic agent, wherein:

  • said immunoglobulin polypeptide or antigen-binding fragment thereof specifically binds to an epitope of a B7-H3L protein that is expressed and exposed in its native conformation on the surface of a cancer cell of said cancer, wherein said epitope is insufficiently expressed on the surface of a living normal cell to exhibit binding by said immunoglobulin polypeptide;

    said immunoglobulin polypeptide or antigen-binding fragment thereof can be internalized into said cancer cell expressing B7-H3L; and

    said immunoglobulin polypeptide or antigen-binding fragment thereof comprises the amino acid sequences of complementarity determining regions of the monoclonal antibody expressed by the hybridoma having ATCC Deposit No. PTA-4217, ATCC Deposit No. PTA-4218, ATCC Deposit No. PTA-4244, or ATCC Deposit No. PTA-4245.

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