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Use of antibody-surrogate antigen systems for detection of analytes

  • US 9,575,069 B2
  • Filed: 11/08/2013
  • Issued: 02/21/2017
  • Est. Priority Date: 03/15/2005
  • Status: Active Grant
First Claim
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1. A labeling molecule useful for specifically labeling a protein comprising:

  • (a) a target moiety;

    (b) a label moiety;

    (c) a photo-activatable reactive moiety; and

    (d) a cleavable tether linking the target moiety to the label moiety;

    wherein the target moiety, label moiety, and reactive moiety are connected to one another such that the target moiety can bind the protein and the reactive moiety can crosslink the labeling molecule to the protein, and wherein the cleavable tether can be cleaved to allow detachment of the target moiety from the protein thereby resulting in a labeled moiety.

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