Method for determining an infusion parameter

• US 9,576,108 B2
• Filed: 02/02/2012
• Issued: 02/21/2017
• Est. Priority Date: 02/02/2012
• Status: Active Grant

• Current Assignee: Brainlab AG, Regents of the University of California (University of California)
• Original Assignee: Brainlab AG
• Inventors: Rosenbluth, Kathryn H., Eschermann, Jan Felix, Doyle, Joseph, Bankiewicz, Krystof, Mittermeyer, Stephan
• Primary Examiner(s): Le, Vu
• Assistant Examiner(s): BEG, SAMAH A
• Application Number:
  US14/371,758
• Publication Number:
  US 20140358114A1
• Time in Patent Office: 1,846 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A method for planning an infusion of a medical substance into a target region acquires non-patient-specific anatomical data from an atlas in the form of target region geometry information describing target and off-target regions for which an infusion of the medical substance is intended and regions to be avoided, respectively. Target coverage information is derived describing a minimum dose of the medical substance to be infused into the target region and describing a maximum dose of the medical substance to be applied to the off-target region. Relationship information describes a relationship between a physical parameter of an infusion setup and a selected spatial distribution of the medical substance. Infusion setup information for the infusion is determined that describes a planned infusion setup and is based on the relationship information and information related to the target and off-target regions.

Claims

1. A data processing method for planning an infusion of a medical substance into a target region of an anatomical body part, wherein the medical substance is to be infused using an associated infusion setup comprising the medical substance and an infusion device for performing the infusion, the method comprising:

acquiring, on a non-patient-specific basis from an associated atlas storing predetermined standard anatomical data, target region geometry data, the target region geometry data comprising target region geometry information describing a position and a geometry of the target region for which an infusion of the medical substance is intended, and a position and a geometry of an off-target region for which application of the medical substance is intended to be avoided;

acquiring, based on the acquired target region geometry data, target coverage data comprising target coverage information describing a planned coverage of the target and off-target regions by the medical substance, wherein the target coverage information comprises information describing a minimum dose of the medical substance to be infused into the target region and information describing a maximum dose of the medical substance to be applied to the off-target region;

acquiring, based on selecting a predetermined spatial distribution of the medical substance in the target region based on the target coverage data, relationship data comprising relationship information which describes a relationship between at least one physical parameter of the associated infusion setup and the selected predetermined spatial distribution of the medical substance, wherein the at least one physical parameter describes at least one of a geometric property of the infusion device, a surface property of the infusion device, a fluid dynamic property of the medical substance, and/or time; and

determining infusion setup data comprising infusion setup information which describes a planned infusion setup, based on the relationship data and the target coverage data.

2. The method according to claim 1, wherein the geometric property of the infusion device comprises at least one of a tip length property, a diameter property and/or a number of outlets or position of a catheter used for the infusion of the medical substance.

3. The method according to claim 1, wherein the surface property of the infusion device comprises at least one of:

a surface roughness of an inner and/or an outer surface of a catheter, and/or

a topology of a catheter used for the infusion of the medical substance.

4. The method according to claim 1, wherein the fluid dynamic property of the infusion device comprises at least one of a pressure property, a flow rate property, a flow velocity property, a fluid resistance property, a viscosity property and/or a density property of the medical substance during the infusion.

5. The method according to claim 1, wherein the selected predetermined spatial distribution of the medical substance has a shape of a convex rotational solid and/or has a geometry which can be described by at least one geometric parameter.

6. The method according to claim 1, wherein the predetermined spatial distribution is selected based on the target region geometry data.

7. The method according to claim 1, wherein the at least one physical parameter of the associated setup is determined based on adapting the predetermined spatial distribution of the medical substance to fit the planned coverage of the target and off-target regions and, when the predetermined spatial distribution of the medical substance has a shape of rotational solid, the at least one physical parameter of the associated setup is determined based on adapting a parameter describing the geometry of the spatial distribution in order to adapt the predetermined spatial distribution of the medical substance to fit the planned coverage of the target and off-target regions.

8. The method according to claim 1, wherein the predetermined spatial distribution and the planned coverage of the target and off-target regions describe at least one of a geometry of the medical substance in the target region and/or a concentration distribution of the medical substance in the target region.

9. The method according to claim 1, further comprising determining the relationship data based on information about at least one geometric property of the infusion device and at least one fluid dynamic property of the medical substance.

10. The method according to claim 1, further comprising determining a medical treatment plan based on the infusion setup data.

11. The method according to claim 1, wherein all of the target region geometry data is acquired on the non-patient-specific basis from the associated atlas storing the predetermined standard anatomical data.

12. A computer program embodied on a non-transitory computer readable medium which, when running on a computer or when loaded onto a computer, causes the computer to perform a data processing method for planning an infusion of a medical substance into a target region of an anatomical body part, wherein the medical substance is to be infused using an associated infusion setup comprising the medical substance and an infusion device for performing the infusion, the method comprising:

acquiring, on a non-patient-specific basis from an associated atlas storing predetermined standard anatomical data, target region geometry data, the target region geometry data comprising target region geometry information describing a position and a geometry of the target region for which an infusion of the medical substance is intended, and a position and a geometry of an off-target region for which application of the medical substance is intended to be avoided;

acquiring, based on the acquired target region geometry data, target coverage data comprising target coverage information describing a planned coverage of the target and off-target regions by the medical substance, wherein the target coverage information comprises information describing a minimum dose of the medical substance to be infused into the target region and information describing a maximum dose of the medical substance to be applied to the off-target region;

acquiring, based on selecting a predetermined spatial distribution of the medical substance in the target region based on the target coverage data, relationship data comprising relationship information which describes a relationship between at least one physical parameter of the associated infusion setup and the selected predetermined spatial distribution of the medical substance, wherein the at least one physical parameter describes at least one of a geometric property of the infusion device, a surface property of the infusion device, a fluid dynamic property of the medical substance, and/or time; and

determining infusion setup data comprising infusion setup information which describes a planned infusion setup, based on the relationship data and the target coverage data.

13. The computer program according to claim 12, wherein all of the target region geometry data is acquired on the non-patient-specific basis from the associated atlas storing the predetermined standard anatomical data.